Overview

  • Product name

    Lappaconitine, analgesic agent 
  • Description

    Centrally acting non-opioid analgesic agent and class-I antiarrhythmic agent
  • Biological description

    Centrally acting non-opioid analgesic agent and class-I antiarrhythmic agent. Binds to the site-2 receptor and irreversibly blocks hH1 sodium channels. Shows analgesic effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    32854-75-4
  • Chemical structure

    Chemical Structure

Properties

  • Molecular weight

    584.70
  • Storage instructions

    Store at +4°C. The product can be stored for up to 12 months.
  • Solubility overview

    Partially soluble in ethanol
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Bryzgalov AO  et al. Lappaconitine: influence of halogen substituent on the antiarrhythmic activity. Cardiovasc Hematol Agents Med Chem 11:211-7 (2013). Read more (PubMed: 23763697) »
  • Wright SN Irreversible block of human heart (hH1) sodium channels by the plant alkaloid lappaconitine. Mol Pharmacol 59:183-92 (2001). Read more (PubMed: 11160852) »
  • Ono M & Satoh T Pharmacological studies of lappaconitine. Analgesia produced by intracerebroventricular, intracisternal and intrathecal injections. J Pharmacobiodyn 13:374-7 (1990). Read more (PubMed: 2231269) »
  • Ono M & Satoh T Pharmacological studies of lappaconitine. Analgesic activities. Arzneimittelforschung 38:892-5 (1988). Read more (PubMed: 3207434) »

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