Product nameLappaconitine, analgesic agent
DescriptionCentrally acting non-opioid analgesic agent and class-I antiarrhythmic agent
Biological descriptionCentrally acting non-opioid analgesic agent and class-I antiarrhythmic agent. Binds to the site-2 receptor and irreversibly blocks hH1 sodium channels. Shows analgesic effects in vivo. Orally active.
Storage instructionsStore at +4°C. The product can be stored for up to 12 months.
Solubility overviewPartially soluble in ethanol
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
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This product has been referenced in:
- Bryzgalov AO et al. Lappaconitine: influence of halogen substituent on the antiarrhythmic activity. Cardiovasc Hematol Agents Med Chem 11:211-7 (2013). Read more (PubMed: 23763697) »
- Wright SN Irreversible block of human heart (hH1) sodium channels by the plant alkaloid lappaconitine. Mol Pharmacol 59:183-92 (2001). Read more (PubMed: 11160852) »
- Ono M & Satoh T Pharmacological studies of lappaconitine. Analgesia produced by intracerebroventricular, intracisternal and intrathecal injections. J Pharmacobiodyn 13:374-7 (1990). Read more (PubMed: 2231269) »
- Ono M & Satoh T Pharmacological studies of lappaconitine. Analgesic activities. Arzneimittelforschung 38:892-5 (1988). Read more (PubMed: 3207434) »