Product nameAnti-LARG antibody
See all LARG primary antibodies
DescriptionRabbit polyclonal to LARG
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat
Synthetic peptide derived from internal sequence of Human LARG.
- HUVEC cell lysate
Storage instructionsShipped at 4°C. Store at -20ºC.
Storage bufferpH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol, 0.88% Sodium chloride
Note: PBS without Mg2+ and Ca2+
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab136072 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/1000. Predicted molecular weight: 173 kDa.|
FunctionMay play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.
Tissue specificityUbiquitously expressed. Isoform 2 is found in jejunum and testis.
Involvement in diseaseA chromosomal aberration involving ARHGEF12 may be a cause of acute leukemia. Translocation t(11;11)(q23;23) with KMT2A/MLL1.
Sequence similaritiesContains 1 DH (DBL-homology) domain.
Contains 1 PDZ (DHR) domain.
Contains 1 PH domain.
Contains 1 RGSL (RGS-like) domain.
Cellular localizationCytoplasm. Membrane. Translocated to the membrane upon stimulation.
- Information by UniProt
- ARHGC_HUMAN antibody
- ARHGEF12 antibody
- KIAA0382 antibody
This product has been referenced in:
- Fong V et al. Arhgef12 drives IL17A-induced airway contractility and airway hyperresponsiveness in mice. JCI Insight 3:N/A (2018). Read more (PubMed: 30385725) »
- Cai J et al. A RhoA-YAP-c-Myc signaling axis promotes the development of polycystic kidney disease. Genes Dev 32:781-793 (2018). Read more (PubMed: 29891559) »