Overview

  • Product name

  • Description

    Rabbit polyclonal to LARG
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat
  • Immunogen

    Synthetic peptide derived from internal sequence of Human LARG.

  • Positive control

    • HUVEC cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab136072 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/1000. Predicted molecular weight: 173 kDa.

Target

  • Function

    May play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13). Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase and may act as GTPase-activating protein (GAP) for GNA12 and GNA13.
  • Tissue specificity

    Ubiquitously expressed. Isoform 2 is found in jejunum and testis.
  • Involvement in disease

    A chromosomal aberration involving ARHGEF12 may be a cause of acute leukemia. Translocation t(11;11)(q23;23) with KMT2A/MLL1.
  • Sequence similarities

    Contains 1 DH (DBL-homology) domain.
    Contains 1 PDZ (DHR) domain.
    Contains 1 PH domain.
    Contains 1 RGSL (RGS-like) domain.
  • Cellular localization

    Cytoplasm. Membrane. Translocated to the membrane upon stimulation.
  • Information by UniProt
  • Database links

  • Alternative names

    • ARHGC_HUMAN antibody
    • ARHGEF12 antibody
    • KIAA0382 antibody
    • leukemia-associated rho guanine nucleotide exchange factor antibody
    • Leukemia-associated RhoGEF antibody
    • PRO2792 antibody
    • Rho guanine exchange factor (GEF) 12 antibody
    • Rho guanine nucleotide exchange factor (GEF) 12 antibody
    • Rho guanine nucleotide exchange factor 12 antibody
    • Similar to Mouse Lsc oncogene antibody
    see all

Images

  • Anti-LARG antibody (ab136072) at 1/500 dilution + HUVEC cell lysate at 30 µg

    Predicted band size: 173 kDa

References

This product has been referenced in:

See all 2 Publications for this product

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