Overview

  • Product name

    Latrunculin B, actin polymerization inhibitor
  • Description

    Cell-permeable actin polymerization inhibitor
  • Biological description

    Cell-permeable actin polymerization inhibitor. Forms a 1:1 complex with monomeric G-actin. Shows less potent growth inhibition effects on cancer cell lines than Latrunculin A, (ab144290) (IC50 values are 7.1 and 4.8 μM for HCT116 and MDA-MB-435 cells respectively). Shows antiglaucoma effects in vivo.
  • Purity

    > 96%
  • CAS Number

    76343-94-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (4R)-4-[(1R,4S,5Z,9Z,13R,15R)-15-Hydroxy-4,9-dimethyl-11-oxo-12,16-dioxabicyclo[11.3.1]heptadeca-5,9-dien-15-yl]-1,3-thiazolidin-2-one

  • Molecular weight

    395.51
  • Molecular formula

    C20H29NO5S
  • PubChem identifier

    6436219
  • Storage instructions

    Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    Soluble in DMSO (25 mg/ml) or ethanol (25 mg/ml)

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C[C@H]/1CC[C@@H]2C[C@H](C[C@@](O2)([C@@H]3CSC(=O)N3)O)OC(=O)/C=C(\CC/C=C1)/C
  • Source

    Latrunculia magnifica

  • Research areas

References

This product has been referenced in:

  • Bozavikov P  et al. Particle size influences fibronectin internalization and degradation by fibroblasts. Exp Cell Res 328:172-85 (2014). Read more (PubMed: 24995996) »
  • Moscatelli A  et al. Inhibition of actin polymerisation by low concentration Latrunculin B affects endocytosis and alters exocytosis in shank and tip of tobacco pollen tubes. Plant Biol (Stuttg) : (2012). Read more (PubMed: 22288466) »
  • Wakatsuki T  et al. Effects of cytochalasin D and latrunculin B on mechanical properties of cells. J Cell Sci 114:1025-36 (2001). Read more (PubMed: 11181185) »
See all 3 Publications for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab144291.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
For licensing inquiries, please contact partnerships@abcam.com

Sign up