• Nature

Associated products


Our Abpromise guarantee covers the use of ab52217 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking - Blocking peptide for Anti-Lck antibody (ab18896)

  • Purity
    > 90 % SDS-PAGE.

  • Form
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: 0.02% Thimerosal (merthiolate)
    Constituents: 0.1% BSA, PBS, pH 7.2

General Info

  • Alternative names
    • IMD22
    • LCK
    • Lck p56
    • LCK proto-oncogene, Src family tyrosine kinase
    • Leukocyte C-terminal Src kinase
    • LSK
    • Lymphocyte cell specific protein tyrosine kinase
    • Lymphocyte cell-specific protein-tyrosine kinase
    • Lymphocyte specific protein tyrosine kinase
    • Membrane associated protein tyrosine kinase
    • Oncogene lck
    • P56 LCK
    • p56(LSTRA) protein tyrosine kinase
    • p56-LCK
    • p56lck
    • pp58 lck
    • pp58lck
    • Protein YT16
    • Proto oncogene tyrosine protein kinase LCK
    • Proto-oncogene Lck
    • Protooncogene tyrosine protein kinase LCK
    • T cell specific protein tyrosine kinase
    • T cell-specific protein-tyrosine kinase
    • T lymphocyte specific protein tyrosine kinase p56lck
    • Tyrosine-protein kinase Lck
    • YT 16
    • YT16
    see all
  • Function
    Tyrosine kinase that plays an essential role for the selection and maturation of developing T-cell in the thymus and in mature T-cell function. Is constitutively associated with the cytoplasmic portions of the CD4 and CD8 surface receptors and plays a key role in T-cell antigen receptor(TCR)-linked signal transduction pathways. Association of the TCR with a peptide antigen-bound MHC complex facilitates the interaction of CD4 and CD8 with MHC class II and class I molecules, respectively, and thereby recruits the associated LCK to the vicinity of the TCR/CD3 complex. LCK then phosphorylates tyrosines residues within the immunoreceptor tyrosines-based activation motifs (ITAMs) in the cytoplasmic tails of the TCRgamma chains and CD3 subunits, initiating the TCR/CD3 signaling pathway. In addition, contributes to signaling by other receptor molecules. Associates directly with the cytoplasmic tail of CD2, and upon engagement of the CD2 molecule, LCK undergoes hyperphosphorylation and activation. Also plays a role in the IL2 receptor-linked signaling pathway that controls T-cell proliferative response. Binding of IL2 to its receptor results in increased activity of LCK. Is expressed at all stages of thymocyte development and is required for the regulation of maturation events that are governed by both pre-TCR and mature alpha beta TCR. Phosphorylates RUNX3.
  • Tissue specificity
    Expressed specifically in lymphoid cells.
  • Involvement in disease
    Note=A chromosomal aberration involving LCK is found in leukemias. Translocation t(1;7)(p34;q34) with TCRB.
  • Sequence similarities
    Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
    Contains 1 protein kinase domain.
    Contains 1 SH2 domain.
    Contains 1 SH3 domain.
  • Domain
    The SH2 domain mediates interaction with SQSTM1. Interaction is regulated by Ser-59 phosphorylation.
  • Post-translational
    Phosphorylated on Tyr-394, which increases enzymatic activity (By similarity). Phosphorylated on Tyr-505, which decreases activity.
  • Cellular localization
    Cytoplasm. Cell membrane. Present in lipid rafts in an unactive form.
  • Information by UniProt


ab52217 has not yet been referenced specifically in any publications.

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