Overview

  • Product name

  • Description

    Rabbit polyclonal to LCLAT1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    antigen sequence, corresponding to amino acids 231-307 (LHPRTTGFTF VVDRLREGKN LDAVHDITVA YPHNIPQSEK HLLQGDFPRE IHFHVHRYPI DTLPTSKEDL QLWCHKR) of Human LCLAT1.

  • Positive control

    • Human heart muscle tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab122197 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/200 - 1/500. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Target

  • Function

    Acyl-CoA:lysocardiolipin acyltransferase. Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities. Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors. Acts as a remodeling enzyme for cardiolipin, a major membrane polyglycerophospholipid. Converts lysophosphatidic acid (LPA) into phosphatidic acid (PA) with a relatively low activity. Required for establishment of the hematopoietic and endothelial lineages.
  • Tissue specificity

    Expressed at higher level in heart, kidney and pancreas than in brain, spleen, liver, lung, small intestine and placenta.
  • Pathway

    Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.
  • Sequence similarities

    Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
  • Domain

    The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
  • Cellular localization

    Endoplasmic reticulum membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • 1-acylglycerol-3-phosphate O-acyltransferase 8 antibody
    • 1-AGP acyltransferase 8 antibody
    • 1-AGPAT 8 antibody
    • 1AGPAT8 antibody
    • Acyl-CoA:lysocardiolipin acyltransferase 1 antibody
    • AGPAT8 antibody
    • ALCAT1 antibody
    • HSRG1849 antibody
    • lclat1 antibody
    • LCLT1_HUMAN antibody
    • LYCAT antibody
    • Lysocardiolipin acyltransferase 1 antibody
    • UNQ1849 antibody
    • UNQ1849/PRO3579 antibody
    see all

Images

  • ab122197 at 1/450 dilution staining LCLAT1 in Paraffin-embedded Human Heart muscle tissue by Immunohistochemistry.

References

ab122197 has not yet been referenced specifically in any publications.

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