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    lclat1-antibody-ab153987.pdf

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Signal Transduction Signaling Pathway Lipid Signaling Lipid Phosphatases
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Anti-LCLAT1 antibody (ab153987)

  • Datasheet
  • SDS
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Western blot - Anti-LCLAT1 antibody (ab153987)

    Key features and details

    • Rabbit polyclonal to LCLAT1
    • Suitable for: WB
    • Reacts with: Human
    • Isotype: IgG

    You may also be interested in

    Secondary
    Product image
    Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

    View more associated products

    Overview

    • Product name

      Anti-LCLAT1 antibody
      See all LCLAT1 primary antibodies
    • Description

      Rabbit polyclonal to LCLAT1
    • Host species

      Rabbit
    • Tested Applications & Species

      Application Species
      WB
      Human
      See all applications and species data
    • Immunogen

      A recombinant fragment corresponding to a region within amino acids 193 and 414 of Human LCLAT1 (Uniprot ID Q6UWP7).

    • Positive control

      • Hela membrane and whole cell lysates.

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
    • Storage buffer

      pH: 7.00
      Preservative: 0.01% Thimerosal (merthiolate)
      Constituents: 78.99% PBS, 1% BSA, 20% Glycerol (glycerin, glycerine)
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Signal Transduction
      • Signaling Pathway
      • Lipid Signaling
      • Lipid Phosphatases
      • Metabolism
      • Pathways and Processes
      • Mitochondrial Metabolism
      • Mitochondrial markers
      • Metabolism
      • Pathways and Processes
      • Metabolic signaling pathways
      • Lipid and lipoprotein metabolism
      • Lipid metabolism

    Associated products

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
    • Positive Controls

      • HeLa whole cell lysate (ab150035)
      • HeLa whole cell lysate (ab29545)
      • HeLa membrane extract lysate (ab29547)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab153987 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Guaranteed

    Tested applications are guaranteed to work and covered by our Abpromise guarantee.

    Predicted

    Predicted to work for this combination of applications and species but not guaranteed.

    Incompatible

    Does not work for this combination of applications and species.

    Application Species
    WB
    Human
    All applications
    Mouse
    Pig
    Application Abreviews Notes
    WB
    1/500 - 1/3000. Predicted molecular weight: 49 kDa.
    Notes
    WB
    1/500 - 1/3000. Predicted molecular weight: 49 kDa.

    Target

    • Function

      Acyl-CoA:lysocardiolipin acyltransferase. Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities. Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors. Acts as a remodeling enzyme for cardiolipin, a major membrane polyglycerophospholipid. Converts lysophosphatidic acid (LPA) into phosphatidic acid (PA) with a relatively low activity. Required for establishment of the hematopoietic and endothelial lineages.
    • Tissue specificity

      Expressed at higher level in heart, kidney and pancreas than in brain, spleen, liver, lung, small intestine and placenta.
    • Pathway

      Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3.
    • Sequence similarities

      Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.
    • Domain

      The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
    • Cellular localization

      Endoplasmic reticulum membrane.
    • Target information above from: UniProt accession Q6UWP7 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 253558 Human
      • Entrez Gene: 225010 Mouse
      • Entrez Gene: 100217396 Pig
      • Omim: 614241 Human
      • SwissProt: Q6UWP7 Human
      • SwissProt: Q3UN02 Mouse
      • Unigene: 468048 Human
      • Unigene: 662770 Human
      • Unigene: 329194 Mouse
      see all
    • Alternative names

      • 1-acylglycerol-3-phosphate O-acyltransferase 8 antibody
      • 1-AGP acyltransferase 8 antibody
      • 1-AGPAT 8 antibody
      • 1AGPAT8 antibody
      • Acyl-CoA:lysocardiolipin acyltransferase 1 antibody
      • AGPAT8 antibody
      • ALCAT1 antibody
      • HSRG1849 antibody
      • lclat1 antibody
      • LCLT1_HUMAN antibody
      • LYCAT antibody
      • Lysocardiolipin acyltransferase 1 antibody
      • UNQ1849 antibody
      • UNQ1849/PRO3579 antibody
      see all

    Images

    • Western blot - Anti-LCLAT1 antibody (ab153987)
      Western blot - Anti-LCLAT1 antibody (ab153987)
      All lanes : Anti-LCLAT1 antibody (ab153987) at 1/500 dilution

      Lane 1 : HeLa whole cell lysate
      Lane 2 : HeLa membrane lysate

      Lysates/proteins at 20 µg per lane.

      Predicted band size: 49 kDa



      10% SDS PAGE

    Protocols

    • Western blot protocols

    Click here to view the general protocols

    Datasheets and documents

    • Datasheet
    • SDS
  • References (0)

    Publishing research using ab153987? Please let us know so that we can cite the reference in this datasheet.

    ab153987 has not yet been referenced specifically in any publications.

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