Anti-LCLAT1 antibody (ab153987)
Key features and details
- Rabbit polyclonal to LCLAT1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-LCLAT1 antibody
See all LCLAT1 primary antibodies -
Description
Rabbit polyclonal to LCLAT1 -
Host species
Rabbit -
Tested Applications & Species
See all applications and species dataApplication Species WB Human
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Immunogen
A recombinant fragment corresponding to a region within amino acids 193 and 414 of Human LCLAT1 (Uniprot ID Q6UWP7).
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Positive control
- Hela membrane and whole cell lysates.
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.00
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 78.99% PBS, 1% BSA, 20% Glycerol (glycerin, glycerine) -
Concentration information loading... -
Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
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Positive Controls
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab153987 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Tested applications are guaranteed to work and covered by our Abpromise guarantee.
Predicted to work for this combination of applications and species but not guaranteed.
Does not work for this combination of applications and species.
| Application | Species |
|---|---|
| WB |
Human
|
| All applications |
Mouse
Pig
|
| Application | Abreviews | Notes |
|---|---|---|
| WB |
1/500 - 1/3000. Predicted molecular weight: 49 kDa.
|
| Notes |
|---|
|
WB
1/500 - 1/3000. Predicted molecular weight: 49 kDa. |
Target
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Function
Acyl-CoA:lysocardiolipin acyltransferase. Possesses both lysophosphatidylinositol acyltransferase (LPIAT) and lysophosphatidylglycerol acyltransferase (LPGAT) activities. Recognizes both monolysocardiolipin and dilysocardiolipin as substrates with a preference for linoleoyl-CoA and oleoyl-CoA as acyl donors. Acts as a remodeling enzyme for cardiolipin, a major membrane polyglycerophospholipid. Converts lysophosphatidic acid (LPA) into phosphatidic acid (PA) with a relatively low activity. Required for establishment of the hematopoietic and endothelial lineages. -
Tissue specificity
Expressed at higher level in heart, kidney and pancreas than in brain, spleen, liver, lung, small intestine and placenta. -
Pathway
Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 2/3. -
Sequence similarities
Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. -
Domain
The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. -
Cellular localization
Endoplasmic reticulum membrane. - Information by UniProt
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Database links
- Entrez Gene: 253558 Human
- Entrez Gene: 225010 Mouse
- Entrez Gene: 100217396 Pig
- Omim: 614241 Human
- SwissProt: Q6UWP7 Human
- SwissProt: Q3UN02 Mouse
- Unigene: 468048 Human
- Unigene: 662770 Human
see all -
Alternative names
- 1-acylglycerol-3-phosphate O-acyltransferase 8 antibody
- 1-AGP acyltransferase 8 antibody
- 1-AGPAT 8 antibody
see all
Images
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Western blot - Anti-LCLAT1 antibody (ab153987)All lanes : Anti-LCLAT1 antibody (ab153987) at 1/500 dilution
Lane 1 : HeLa whole cell lysate
Lane 2 : HeLa membrane lysate
Lysates/proteins at 20 µg per lane.
Predicted band size: 49 kDa
10% SDS PAGE
References (0)
ab153987 has not yet been referenced specifically in any publications.
