Overview

  • Product name
    Anti-LDL (Copper oxidized) antibody
  • Description
    Rabbit polyclonal to LDL (Copper oxidized)
  • Host species
    Rabbit
  • Tested applications
    Suitable for: ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Human Cu2+ oxidised LDL.

Applications

Our Abpromise guarantee covers the use of ab14519 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA
IHC-P
  • Application notes
    ELISA: 1/500 - 1/5000.
    IHC-P: <1/500.

    Not tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Relevance
      When too much LDL cholesterol circulates in the blood, it can slowly build up in the inner walls of the arteries that feed the heart and brain. Together with other substances it can form plaque, a thick, hard deposit that can clog those arteries. This condition is known as atherosclerosis. Oxidized lipoproteins are formed by free radical damage to lipids that accumulate in macrophages and smooth muscle cells causing foam cell formation, an initial step in the disease.
    • Cellular localization
      Secreted (probable)

    References

    This product has been referenced in:
    • Ying Y  et al. EBF1 gene polymorphism and its interaction with smoking and drinking on the risk of coronary artery disease for Chinese patients. Biosci Rep 38:N/A (2018). Read more (PubMed: 29789399) »
    • Li R  et al. Role of liver sinusoidal endothelial cells and stabilins in elimination of oxidized low-density lipoproteins. Am J Physiol Gastrointest Liver Physiol 300:G71-81 (2011). Read more (PubMed: 21030611) »
    See all 6 Publications for this product

    Customer reviews and Q&As

    1-2 of 2 Abreviews or Q&A

    Application
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
    Sample
    Rat Tissue sections (Lung)
    Antigen retrieval step
    Heat mediated - Buffer/Enzyme Used: Citrate buffer PH6.0
    Permeabilization
    No
    Specification
    Lung
    Blocking step
    Serum as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: 25°C
    Fixative
    Paraformaldehyde

    Abcam user community

    Verified customer

    Submitted Aug 09 2015

    Answer

    Thank you for your enquiry. ab14519 is the only anti-LDL "Copper oxidised" antiserum that we stock. Please can you tell me whether your customer is interested in the oxidised form of the protein or the native equivalent as our antisera carry this specificity. I hope this information helps. Please do not hesitate to contact me should you require further assistance.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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