Overview

  • Product name

    LDN-57444, UCH-L1 inhibitor
  • Description

    Reversible, competitive UCH-L1 inhibitor
  • Biological description

    Reversible, competitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor (Ki = 0.4 μM. Increases ubiquitinated protein levels and decreases proteasome activity. Also induces apoptosis.
  • Purity

    > 98%
  • CAS Number

    668467-91-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    [(Z)-[5-Chloro-1-[(2,5-dichlorophenyl)methyl]-2-oxoindol-3-ylidene]amino] acetate
  • Molecular weight

    397.64
  • Molecular formula

    C17H11Cl3N2O3
  • PubChem identifier

    16760696
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(=O)ON=C1C2=C(C=CC(=C2)Cl)N(C1=O)CC3=C(C=CC(=C3)Cl)Cl
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Cartier AE  et al. Regulation of synaptic structure by ubiquitin C-terminal hydrolase L1. J Neurosci 29:7857-68 (2009). Read more (PubMed: 19535597) »
  • Tan YY  et al. Endoplasmic reticulum stress contributes to the cell death induced by UCH-L1 inhibitor. Mol Cell Biochem 318:109-15 (2008). Read more (PubMed: 18622688) »
  • Liu Y  et al. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem Biol 10:837-46 (2003). Read more (PubMed: 14522054) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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