Leelamine, Pyruvate dehydrogenase kinase (PDK) inhibitor (ab120923)

Overview

  • Product name

    Leelamine, Pyruvate dehydrogenase kinase (PDK) inhibitor
  • Description

    Pyruvate dehydrogenase kinase (PDK) inhibitor
  • Alternative names

    • Dehydroabietylamine
  • Biological description

    Pyruvate dehydrogenase kinase (PDK) inhibitor (IC50 = 9.5 µM). It has weak affinity for human CB1 and CB2 receptors, exhibiting 20% displacement of [3H]-CP55940 at a concentration of 10 µM.
  • Purity

    > 98%
  • CAS Number

    1446-61-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (1R,4aS,10aR)-1,2,3,4,4a,9,10,10a-Octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine
  • Molecular weight

    285.47
  • Molecular formula

    C20H31N
  • Storage instructions

    Store at room temperature.
  • Solubility overview

    Supplied in ethanol (50 mg/ml)
  • Handling

    Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 6 months. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(C)C(C=C1)=CC2=C1[C@]3(C)[C@](CC2)([H])[C@@](CN)(C)CCC3
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Cadoudal T  et al. Pyruvate dehydrogenase kinase 4: regulation by thiazolidinediones and implication in glyceroneogenesis in adipose tissue. Diabetes 57:2272-9 (2008). Read more (PubMed: 18519799) »
  • Aicher TD  et al. Triterpene and diterpene inhibitors of pyruvate dehydrogenase kinase (PDK). Bioorg Med Chem Lett 9:2223-8 (1999). Read more (PubMed: 10465550) »

Customer reviews and Q&As

Answer

The leelamine is probably coming out of solution at that temperature. We recommend storing it at room temperature. It will be stable for at least one year.

Read More

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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