Overview

  • Product name

    Leflunomide, Immunomodulatory agent
  • Description

    Immunomodulatory agent
  • Biological description

    Immunomodulatory agent. Inhibits dihydroorotate dehydrogenase (Ki = 2.7 μM). Inhibits T and B cell activity and prevents lymphocyte cell cycle proliferation and progression. Also shows anti-inflammatory activity. Active In vivo.
  • Purity

    > 98%
  • CAS Number

    75706-12-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    5-Methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
  • Molecular weight

    270.21
  • Molecular formula

    C12H9F3N2O2
  • PubChem identifier

    3899
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC1=C(C=NO1)C(=O)NC2=CC=C(C=C2)C(F)(F)F
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Magari K  et al. Comparison of anti-arthritic properties of leflunomide with methotrexate and FK506: effect on T cell activation-induced inflammatory cytokine production in vitro and rat adjuvant-induced arthritis. Inflamm Res 53:544-50 (2004). Read more (PubMed: 15597149) »
  • Cherwinski HM  et al. The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis. J Pharmacol Exp Ther 275:1043-9 (1995). Read more (PubMed: 7473131) »
  • Greene S  et al. Inhibition of dihydroorotate dehydrogenase by the immunosuppressive agent leflunomide. Biochem Pharmacol 50:861-7 (1995). Read more (PubMed: 7575649) »

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