• Product name

  • Description

    Rabbit polyclonal to LEPRE1/P3H1
  • Host species

  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: IP
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human LEPRE1/P3H1 aa 200-250. The exact sequence is proprietary.
    Database link: Q32P28

  • Positive control

    • WB: HeLa, HEK-293T and Jurkat whole cell lysates.
  • General notes

     This product was previously labelled as LEPRE1




Our Abpromise guarantee covers the use of ab241480 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/2000 - 1/10000. Predicted molecular weight: 83 kDa.
  • Application notes
    Is unsuitable for IP.
  • Target

    • Function

      Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts.
    • Involvement in disease

      Defects in LEPRE1 are the cause of osteogenesis imperfecta type 8 (OI8) [MIM:610915]. A connective tissue disorder characterized by disproportionate short stature, severe osteoporosis, shortening of the long bones, white sclerae, a round face and a short barrel-shaped chest.
    • Sequence similarities

      Belongs to the leprecan family.
      Contains 1 Fe2OG dioxygenase domain.
      Contains 4 TPR repeats.
    • Post-translational

      O-glycosylated; chondroitin sulfate.
    • Cellular localization

      Endoplasmic reticulum. Secreted > extracellular space > extracellular matrix. Secreted into the extracellular matrix as a chondroitin sulfate proteoglycan.
    • Information by UniProt
    • Database links

    • Alternative names

      • GROS 1 antibody
      • GROS1 antibody
      • Growth suppressor 1 antibody
      • LEPRE 1 antibody
      • Lepre1 antibody
      • Leprecan 1 antibody
      • Leprecan antibody
      • Leprecan-1 antibody
      • Leprecan1 antibody
      • Leucine proline enriched proteoglycan (leprecan) 1 antibody
      • Leucine proline enriched proteoglycan 1 antibody
      • Leucine- and proline-enriched proteoglycan 1 antibody
      • MGC117314 antibody
      • OI8 antibody
      • P3H1 antibody
      • P3H1_HUMAN antibody
      • Prolyl 3 hydroxylase 1 antibody
      • Prolyl 3-hydroxylase 1 antibody
      see all


    • All lanes : Anti-LEPRE1/P3H1 antibody (ab241480) at 0.1 µg/ml

      Lane 1 : HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate
      Lane 2 : HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate
      Lane 3 : Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate

      Lysates/proteins at 50 µg per lane.

      Developed using the ECL technique.

      Predicted band size: 83 kDa

      Exposure time: 3 minutes

      Lysates prepared in NETN lysis buffer.


    ab241480 has not yet been referenced specifically in any publications.

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