Overview

  • Product name

  • Description

    Rabbit polyclonal to LEPRE1/P3H1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
    Unsuitable for: IP
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human LEPRE1/P3H1 aa 200-250. The exact sequence is proprietary.
    Database link: Q32P28

  • Positive control

    • WB: HeLa, HEK-293T and Jurkat whole cell lysates.
  • General notes

     This product was previously labelled as LEPRE1

     

Properties

Applications

Our Abpromise guarantee covers the use of ab241480 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/2000 - 1/10000. Predicted molecular weight: 83 kDa.
  • Application notes
    Is unsuitable for IP.
  • Target

    • Function

      Basement membrane-associated chondroitin sulfate proteoglycan (CSPG). Has prolyl 3-hydroxylase activity catalyzing the post-translational formation of 3-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens, especially types IV and V. May be involved in the secretory pathway of cells. Has growth suppressive activity in fibroblasts.
    • Involvement in disease

      Defects in LEPRE1 are the cause of osteogenesis imperfecta type 8 (OI8) [MIM:610915]. A connective tissue disorder characterized by disproportionate short stature, severe osteoporosis, shortening of the long bones, white sclerae, a round face and a short barrel-shaped chest.
    • Sequence similarities

      Belongs to the leprecan family.
      Contains 1 Fe2OG dioxygenase domain.
      Contains 4 TPR repeats.
    • Post-translational
      modifications

      O-glycosylated; chondroitin sulfate.
    • Cellular localization

      Endoplasmic reticulum. Secreted > extracellular space > extracellular matrix. Secreted into the extracellular matrix as a chondroitin sulfate proteoglycan.
    • Information by UniProt
    • Database links

    • Alternative names

      • GROS 1 antibody
      • GROS1 antibody
      • Growth suppressor 1 antibody
      • LEPRE 1 antibody
      • Lepre1 antibody
      • Leprecan 1 antibody
      • Leprecan antibody
      • Leprecan-1 antibody
      • Leprecan1 antibody
      • Leucine proline enriched proteoglycan (leprecan) 1 antibody
      • Leucine proline enriched proteoglycan 1 antibody
      • Leucine- and proline-enriched proteoglycan 1 antibody
      • MGC117314 antibody
      • OI8 antibody
      • P3H1 antibody
      • P3H1_HUMAN antibody
      • Prolyl 3 hydroxylase 1 antibody
      • Prolyl 3-hydroxylase 1 antibody
      see all

    Images

    • All lanes : Anti-LEPRE1/P3H1 antibody (ab241480) at 0.1 µg/ml

      Lane 1 : HeLa (human epithelial cell line from cervix adenocarcinoma) whole cell lysate
      Lane 2 : HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate
      Lane 3 : Jurkat (human T cell leukemia cell line from peripheral blood) whole cell lysate

      Lysates/proteins at 50 µg per lane.

      Developed using the ECL technique.

      Predicted band size: 83 kDa


      Exposure time: 3 minutes


      Lysates prepared in NETN lysis buffer.

    References

    ab241480 has not yet been referenced specifically in any publications.

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