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    leptin-receptor-peptide-ab5837.pdf

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Signal Transduction Growth Factors/Hormones Hormones
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Leptin Receptor peptide (ab5837)

  • Datasheet
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Key features and details

  • Purity: > 95% SDS-PAGE
  • Suitable for: Blocking

Description

  • Product name

    Leptin Receptor peptide
    See all Leptin Receptor proteins and peptides
  • Purity

    > 95 % SDS-PAGE.

  • Animal free

    No
  • Nature

    Synthetic

Associated products

  • Positive Controls

    • Anti-Leptin Receptor antibody (ab5593)

Specifications

Our Abpromise guarantee covers the use of ab5837 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form

    Lyophilized
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Store at -20°C or -80°C. Avoid freeze / thaw cycle.

  • Reconstitution
    Reconstitute with 0.1 ml of distilled water.

General Info

  • Alternative names

    • CD 295
    • CD295
    • CD295 antigen
    • Db
    • Fa
    • HuB219
    • LEP R
    • LEP-R
    • LEPR
    • LEPR_HUMAN
    • LEPRD
    • Leptin receptor
    • Leptin receptor fatty
    • Leptin receptor gene related protein
    • Leptin receptor precursor
    • OB R gene related protein
    • OB receptor
    • OB-R
    • OB-RGRP
    • obl
    • Obr
    see all
  • Function

    Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway.
  • Tissue specificity

    Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus.
  • Sequence similarities

    Belongs to the type I cytokine receptor family. Type 2 subfamily.
    Contains 4 fibronectin type-III domains.
    Contains 1 Ig-like (immunoglobulin-like) domain.
  • Domain

    The cytoplasmic domain may be essential for intracellular signal transduction by activation of JAK tyrosine kinase and STATs.
    The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
    The box 1 motif is required for JAK interaction and/or activation.
  • Post-translational
    modifications

    On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-986 is required for complete binding and activation of PTPN11, ERK/FOS activation and, for interaction with SOCS3 (By similarity). Phosphorylation on Tyr-1141 is required for STAT3 binding/activation.
  • Cellular localization

    Secreted and Cell membrane.
  • Target information above from: UniProt accession P48357 The UniProt Consortium
    The Universal Protein Resource (UniProt) in 2010
    Nucleic Acids Res. 38:D142-D148 (2010) .

    Information by UniProt

Protocols

To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

Click here to view the general protocols

Datasheets and documents

    • Datasheet
  • References (0)

    Publishing research using ab5837? Please let us know so that we can cite the reference in this datasheet.

    ab5837 has not yet been referenced specifically in any publications.

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