Lestaurtinib, JAK2, FLT3 and TrkA receptor tyrosine kinase inhibitor (ab142107)
Key features and details
- Potent JAK2, FLT3 and TrkA receptor tyrosine kinase inhibitor
- CAS Number: 111358-88-4
- Purity: > 98%
- Soluble in DMSO to 10 mM
- Form / State: Solid
- Source: Synthetic
Overview
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Product name
Lestaurtinib, JAK2, FLT3 and TrkA receptor tyrosine kinase inhibitor -
Description
Potent JAK2, FLT3 and TrkA receptor tyrosine kinase inhibitor -
Biological description
Potent JAK2, FLT3 and TrkA receptor tyrosine kinase inhibitor (IC50 values are 0.9, 3 and 25 nM respectively). Antiproliferative effects in vitro. Antileukemic agent in vivo. Orally active. -
Purity
> 98% -
CAS Number
111358-88-4 -
Chemical structure
Properties
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Chemical name
(9S,10S,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocin-1-one -
Molecular weight
439.46 -
Molecular formula
C26H21N3O4 -
PubChem identifier
126565 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(CO)O -
Source
Synthetic
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Research areas
- Biochemicals
- Pharmacology
- Receptors & Transporters
- Enzyme-Linked Receptors
- Receptor tyrosine kinases
- Trk
- Metabolism
- Pathways and Processes
- Metabolic signaling pathways
- Energy transfer pathways
- Energy Metabolism
Images
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Chemical Structure - Lestaurtinib, JAK2, FLT3 and TrkA receptor tyrosine kinase inhibitor (ab142107)2D chemical structure image of ab142107, Lestaurtinib, JAK2, FLT3 and TrkA receptor tyrosine kinase inhibitor
Protocols
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab142107 has been referenced in 2 publications.
- Chang J et al. Exome-wide analysis identifies three low-frequency missense variants associated with pancreatic cancer risk in Chinese populations. Nat Commun 9:3688 (2018). PubMed: 30206226
- Lee M & Rhee I Cytokine Signaling in Tumor Progression. Immune Netw 17:214-227 (2017). PubMed: 28860951