Overview

  • Product name

    Letrozole, Aromatase inhibitor
  • Description

    Highly potent, reversible, selective aromatase inhibitor
  • Biological description

    Highly potent, reversible, selective aromatase inhibitor (IC50 = 11.5 nM). Inhibits estradiol synthesis. Potent antitumor effects in vivo. Cytochrome P450 inhibitor.
  • Purity

    > 99%
  • CAS Number

    112809-51-5
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Vierk R  et al. Aromatase inhibition abolishes LTP generation in female but not in male mice. J Neurosci 32:8116-26 (2012). Read more (PubMed: 22699893) »
  • Bhatnagar AS The discovery and mechanism of action of letrozole. Breast Cancer Res Treat 105 Suppl 1:7-17 (2007). Read more (PubMed: 17912633) »
  • Bhatnagar AS  et al. Highly selective inhibition of estrogen biosynthesis by CGS 20267, a new non-steroidal aromatase inhibitor. J Steroid Biochem Mol Biol 37:1021-7 (1990). Read more (PubMed: 2149502) »

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