The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/1000. Predicted molecular weight: 135 kDa.
Use at an assay dependent concentration.
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs.
Involvement in disease
Infantile liver failure syndrome 1
Belongs to the class-I aminoacyl-tRNA synthetase family.
Park SJ et al. Evaluation of Multi-tRNA Synthetase Complex by Multiple Reaction Monitoring Mass Spectrometry Coupled with Size Exclusion Chromatography. PLoS One10:e0142253 (2015).
Read more (PubMed: 26544075) »
Su X et al. Interferon-? regulates cellular metabolism and mRNA translation to potentiate macrophage activation. Nat Immunol16:838-849 (2015).
Read more (PubMed: 26147685) »