Leukadherin-1, Integrin CD11b/CD19 agonist (ab142214)
- Datasheet
- References
Overview
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Product name
Leukadherin-1, Integrin CD11b/CD19 agonist -
Description
Integrin CD11b/CD19 agonist -
Biological description
Integrin CD11b/CD19 agonist. Increases CD11b/CD18-dependent cell adhesion in vitro resulting in decreased chemotaxis and transendothelial migration. Decreases leukocyte recruitment and reduces arterial narrowing after injury. Preserves kidney function in vivo. -
Purity
> 97% -
CAS Number
344897-95-6 -
Chemical structure
Properties
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Chemical name
4-[5-[(3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl]furan-2-yl]benzoic acid -
Molecular weight
421.49 -
Molecular formula
C22H15NO4S2 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 10 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
C1=CC=C(C=C1)CN2C(=O)C(=CC3=CC=C(O3)C4=CC=C(C=C4)C(=O)O)SC2=S -
Source
Synthetic
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Research areas
References
This product has been referenced in:
- Maiguel D et al. Small molecule-mediated activation of the integrin CD11b/CD18 reduces inflammatory disease. Sci Signal 4:ra57 (2011). Read more (PubMed: 21900205) »
