Overview

  • Product name

    Leukotriene C4, Leukotriene C4 receptor agonist
  • Description

    Potent leukotriene C4 receptor agonist
  • Biological description

    Potent leukotriene C4 receptor agonist (EC50 = 300 nM). Lipid derivative of arachidonic acid and smooth muscle contractant (EC50 = 11 nM). Causes coronary and renal vasoconstriction in vivo.
  • Purity

    > 98%
  • CAS Number

    72025-60-6
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (5S,6R,7E,9E,11Z,14Z)-6-[(2R)-2-[[(4S)-4-Amino-4-carboxybutanoyl]amino]-3-(carboxymethylamino)-3-oxopropyl]sulfanyl-5-hydroxyicosa-7,9,11,14-tetraenoic acid
  • Molecular weight

    625.77
  • Molecular formula

    C30H47N3O9S
  • PubChem identifier

    5280493
  • Storage instructions

    Store at -80°C.
  • Solubility overview

    Supplied in methanol/ammonium acetate buffer, 65:35, pH5.6 (50 µg/ml)
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CCCCCC=CCC=CC=CC=CC(C(CCCC(=O)O)O)SCC(C(=O)NCC(=O)O)NC(=O)CCC(C(=O)O)N
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Sharif NA  et al. Pharmacological analysis of mast cell mediator and neurotransmitter receptors coupled to adenylate cyclase and phospholipase C on immunocytochemically-defined human conjunctival epithelial cells. J Ocul Pharmacol Ther 13:321-36 (1997). Read more (PubMed: 9261768) »
  • Henderson WR The role of leukotrienes in inflammation. Ann Intern Med 121:684-97 (1994). Read more (PubMed: 7944079) »
  • Allen SP  et al. Influence of atherosclerosis on the vascular reactivity of isolated human epicardial coronary arteries to leukotriene C4. Cardioscience 4:47-54 (1993). Read more (PubMed: 8471741) »

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