Overview

  • Product name

    Leukotriene E4, CysLT1 and CysLT2 agonist
  • Description

    Partial, selective CysLT1 and CysLT2 agonist
  • Biological description

    Partial, selective CysLT1 and CysLT2 agonist (EC50 values are 55.9 and 59 nM, respectively). Induces hypotension and bronchoconstriction. Active in vivo and in vitro.
  • Purity

    > 98%
  • CAS Number

    75715-89-8
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Wunder F  et al. Pharmacological characterization of the first potent and selective antagonist at the cysteinyl leukotriene 2 (CysLT(2)) receptor. Br J Pharmacol 160:399-409 (2010). Read more (PubMed: 20423349) »
  • Dahlén SE  et al. Allergen challenge of lung tissue from asthmatics elicits bronchial contraction that correlates with the release of leukotrienes C4, D4, and E4. Proc Natl Acad Sci U S A 80:1712-6 (1983). Read more (PubMed: 6300870) »
  • Drazen JM  et al. Effects of leukotriene E on pulmonary mechanics in the guinea pig. Am Rev Respir Dis 125:290-4 (1982). Read more (PubMed: 6279000) »

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