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Cell Biology Cell Cycle Kinases/Phosphatases Phosphatases
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Levamisole hydrochloride, Alkaline phosphatase inhibitor (ab141217)

  • Datasheet
  • SDS
  • COA
Reviews (2) Submit a question References (1)

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Chemical Structure - Levamisole hydrochloride, Alkaline phosphatase inhibitor (ab141217)

    Key features and details

    • Alkaline phosphatase inhibitor. Selective agonist at nematode nAChRs.
    • CAS Number: 16595-80-5
    • Purity: > 99%
    • Soluble in DMSO to 100 mM and water to 100 mM
    • Form / State: Solid
    • Source: Synthetic

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    Overview

    • Product name

      Levamisole hydrochloride, Alkaline phosphatase inhibitor
    • Description

      Alkaline phosphatase inhibitor. Selective agonist at nematode nAChRs.
    • Biological description

      Alkaline phosphatase inhibitor. Also a selective agonist at nematode nicotinic acetylcholine receptors (nAChRs). Displays anticancer, immunomodulatory and antiparasitic activity.

    • Purity

      > 99%
    • CAS Number

      16595-80-5
    • Chemical structure

      Chemical Structure

    Properties

    • Chemical name

      2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride
    • Molecular weight

      240.75
    • Molecular formula

      C11H12N2S.HCl
    • PubChem identifier

      68628
    • Storage instructions

      Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
    • Solubility overview

      Soluble in DMSO to 100 mM and water to 100 mM
    • Handling

      Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

      Toxic, refer to SDS for further information.

      Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

    • SMILES

      Cl.N1=C3SCCN3C[C@@H]1c2ccccc2
    • Source

      Synthetic

    • Research areas

      • Cell Biology
      • Cell Cycle
      • Kinases/Phosphatases
      • Phosphatases
      • Microbiology
      • Antimicrobial
      • Antibiotic
      • Biochemicals
      • Product Range
      • Just Add Water
      • Biochemicals
      • Chemical Type
      • Biochemicals
      • Biochemicals
      • Chemical Type
      • Antibiotic
      • Biochemicals
      • Pharmacology
      • Signaling
      • Immunomodulators
      • Biochemicals
      • Pharmacology
      • Enzymes
      • Phosphatase
      • Alkaline phosphatase
      • Inhibitors
      • Biochemicals
      • Pharmacology
      • Signaling
      • Immunomodulators
      • Immunomodulators & Immunosuppressants
      • Biochemicals
      • Pharmacology
      • Signaling
      • Immunomodulators
      • Antiparasitic

    Associated products

      Images

      • Chemical Structure - Levamisole hydrochloride, Alkaline phosphatase inhibitor (ab141217)
        Chemical Structure - Levamisole hydrochloride, Alkaline phosphatase inhibitor (ab141217)
        2D chemical structure image of ab141217, Levamisole hydrochloride, Alkaline phosphatase inhibitor

      Protocols

      To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.

      Click here to view the general protocols

      Datasheets and documents

      • SDS download

      • Datasheet download

        Download
      • COA

      References (1)

      Publishing research using ab141217? Please let us know so that we can cite the reference in this datasheet.

      ab141217 has been referenced in 1 publication.

      • Wessely A  et al. Induction of ALP and MMP9 activity facilitates invasive behavior in heterogeneous human BMSC and HNSCC 3D spheroids. FASEB J N/A:fj201900925R (2019). PubMed: 31366234

      Customer reviews and Q&As

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      1-2 of 2 Abreviews or Q&A

      Alkaline Phosphatase Blocking in IHC

      Excellent
      Abreviews
      Abreviews
      We used this product to block endogenous alkaline phosphatase activity in IHC assays using Vector Labs Vector Red chromogen substrate. Adding dissolved levamisole hydrochloride to the chromogen substrate sufficiently blocks alkaline phosphatase activity, including activity in bone tissue.

      Sarah Britton

      Verified customer

      Submitted Sep 16 2019

      Levamisol

      Excellent
      Abreviews
      Abreviews
      We use levamisole to block the endogenous alkaline phosphatase in immunostaining.
      It works very well to avoid nonspecific staining. We added Levamisol to the Substrate solution.

      Abcam user community

      Verified customer

      Submitted Sep 13 2019

      Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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