Levamisole hydrochloride, Alkaline phosphatase inhibitor (ab141217)
- Datasheet
- References
Overview
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Product name
Levamisole hydrochloride, Alkaline phosphatase inhibitor -
Description
Alkaline phosphatase inhibitor. Selective agonist at nematode nAChRs. -
Biological description
Alkaline phosphatase inhibitor. Also a selective agonist at nematode nicotinic acetylcholine receptors (nAChRs). Displays anticancer, immunomodulatory and antiparasitic activity. -
Purity
> 99% -
CAS Number
16595-80-5 -
Chemical structure
Properties
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Chemical name
2,3,5,6-Tetrahydro-6-phenylimidazo[2,1-b]thiazole hydrochloride -
Molecular weight
240.75 -
Molecular formula
C11H12N2S.HCl -
PubChem identifier
68628 -
Storage instructions
Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months. -
Solubility overview
Soluble in DMSO to 100 mM and water to 100 mM -
Handling
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Toxic, refer to SDS for further information.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
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SMILES
Cl.N1=C3SCCN3C[C@@H]1c2ccccc2 -
Source
Synthetic
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Research areas
References
This product has been referenced in:
- Hegde M et al. Novel levamisole derivative induces extrinsic pathway of apoptosis in cancer cells and inhibits tumor progression in mice. PLoS One 7:e43632 (2012). Read more (PubMed: 22970136) »
- Rayes D et al. Molecular basis of the differential sensitivity of nematode and mammalian muscle to the anthelmintic agent levamisole. J Biol Chem 279:36372-81 (2004). Read more (PubMed: 15201284) »
- Trailovic SM et al. Levamisole receptor phosphorylation: effects of kinase antagonists on membrane potential responses in Ascaris suum suggest that CaM kinase and tyrosine kinase regulate sensitivity to levamisole. J Exp Biol 205:3979-88 (2002). Read more (PubMed: 12432019) »
- Lewis JA et al. The levamisole receptor, a cholinergic receptor of the nematode Caenorhabditis elegans. Mol Pharmacol 31:185-93 (1987). Read more (PubMed: 3807894) »
