Overview

  • Product name

    Levetiracetam, Anti-epileptic; binds to SV2A protein
  • Description

    Potent anti-epileptic; binds to SV2A
  • Biological description

    Distinct pharmacological profile in vivo; potent anti-epileptic in chronic seizure models, lacks activity in acute seizure models. Binds to synaptic vesicle protein (SV2A) in the brain.

    Also available in simple stock solutions (ab146733) - add 1 ml of water to get an exact, ready-to-use concentration.
  • Purity

    > 99%
  • CAS Number

    102767-28-2
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    S)-α-Ethyl-2-oxo-1-pyrrolidineacetamide
  • Molecular weight

    170.21
  • Molecular formula

    C8H14N2O2
  • PubChem identifier

    5284583
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in water to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    O=C1CCCN1[C@@H](CC)C(N)=O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Vogl C  et al. The synaptic vesicle glycoprotein 2A ligand levetiracetam inhibits presynaptic Ca2+ channels through an intracellular pathway. Mol Pharmacol 82:199-208 (2012). Read more (PubMed: 22554805) »
  • Ueda Y  et al. Effect of levetiracetam on molecular regulation of hippocampal glutamate and GABA transporters in rats with chronic seizures induced by amygdalar FeCl3 injection. Brain Res 1151:55-61 (2007). Read more (PubMed: 17408599) »
  • Lynch BA  et al. The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proc Natl Acad Sci U S A 101:9861-6 (2004). Read more (PubMed: 15210974) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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