Overview

  • Product name
    Levobupivacaine hydrochloride
  • Description
    Long-acting local anesthetic
  • Alternative names
    • (2S)-1-butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide, hydrochloride (1:1)
    • (S)-(-)-Bupivacaine HCl
    • (S)-1-Butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide hydrochloride
    • (S)-bupivacaine hydrochloride
  • Biological description

    (S)-enantiomer of bupivacaine (ab142490). Reversible sodium channel inhibitor. Acts via blockade of voltage-sensitive ion channels in neuronal membranes, preventing transmission of nerve impulses. Efficacy is similar to that of bupivacaine with a reduced risk of cardiotoxicity.

Properties

  • Chemical name
    (2S)-1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide hydrochloride
  • Molecular weight
    324.89
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C18H28N2O.HCl
  • CAS Number
    27262-48-2
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Toxic, refer to SDS for further information.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:
  • Foster RH & Markham A Levobupivacaine: a review of its pharmacology and use as a local anaesthetic. Drugs 59:551-79 (2000). Read more (PubMed: 10776835) »
  • Vladimirov M  et al. Potency of bupivacaine stereoisomers tested in vitro and in vivo: biochemical, electrophysiological, and neurobehavioral studies. Anesthesiology 93:744-55 (2000). Read more (PubMed: 10969308) »
  • Kanai Y  et al. Comparisons of the anesthetic potency and intracellular concentrations of S(-) and R() bupivacaine and ropivacaine in crayfish giant axon in vitro. Anesth Analg 90:415-20 (2000). Read more (PubMed: 10648331) »
  • Gristwood RW & Greaves JL Levobupivacaine: a new safer long acting local anaesthetic agent. Expert Opin Investig Drugs 8:861-76 (1999). Read more (PubMed: 15992136) »

See 0 Publications for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab145736.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

Sign up