Anti-LGR5 antibody (ab219107)
Key features and details
- Rabbit polyclonal to LGR5
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
Overview
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Product name
Anti-LGR5 antibody
See all LGR5 primary antibodies -
Description
Rabbit polyclonal to LGR5 -
Host species
Rabbit -
Specificity
BLAST analysis of the peptide immunogen showed no homology with other human proteins. -
Tested applications
Suitable for: IHC-Pmore details -
Species reactivity
Reacts with: Human
Predicted to work with: Mouse, Rat, Cow, Monkey, Gorilla, Bat -
Immunogen
Synthetic peptide corresponding to Human LGR5 (extracellular). (20 amino acid peptide from N-terminal extracellular domain).
Database link: O75473 -
Positive control
- IHC-P: Human pancreas, islets tissue.
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General notes
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
Properties
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Form
Liquid -
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
Storage buffer
pH: 7.4
Preservative: 0.09% Sodium azide
Constituent: 99% PBS -
Concentration information loading...
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Purity
Immunogen affinity purified -
Clonality
Polyclonal -
Isotype
IgG -
Research areas
Associated products
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Compatible Secondaries
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Isotype control
Applications
The Abpromise guarantee
Our Abpromise guarantee covers the use of ab219107 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application | Abreviews | Notes |
---|---|---|
IHC-P | (3) |
1/400.
|
Notes |
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IHC-P
1/400. |
Target
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Function
Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicule. Target gene of Wnt signaling. -
Tissue specificity
Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of the ovary, colon and liver. -
Sequence similarities
Belongs to the G-protein coupled receptor 1 family.
Contains 16 LRR (leucine-rich) repeats.
Contains 1 LRRNT domain. -
Cellular localization
Cell membrane. - Information by UniProt
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Database links
- Entrez Gene: 520189 Cow
- Entrez Gene: 8549 Human
- Entrez Gene: 14160 Mouse
- Entrez Gene: 299802 Rat
- Omim: 606667 Human
- SwissProt: F1MT22 Cow
- SwissProt: O75473 Human
- SwissProt: Q9Z1P4 Mouse
see all -
Alternative names
- FEX antibody
- G protein coupled receptor 49 antibody
- G protein coupled receptor 67 antibody
see all
Images
Datasheets and documents
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SDS download
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Datasheet download
References (2)
ab219107 has been referenced in 2 publications.
- Chang ZY et al. Modulation of Gut Microbiota Combined with Upregulation of Intestinal Tight Junction Explains Anti-Inflammatory Effect of Corylin on Colitis-Associated Cancer in Mice. Int J Mol Sci 23:N/A (2022). PubMed: 35269806
- Frick A et al. A Novel PAK1-Notch1 Axis Regulates Crypt Homeostasis in Intestinal Inflammation. Cell Mol Gastroenterol Hepatol 11:892-907.e1 (2021). PubMed: 33189893