Overview

  • Product name

  • Description

    Rabbit polyclonal to LGR5
  • Host species

    Rabbit
  • Specificity

    BLAST analysis of the peptide immunogen showed no homology with other human proteins.
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Monkey, Gorilla, Bat
  • Immunogen

    Synthetic peptide corresponding to Human LGR5 (extracellular). (20 amino acid peptide from N-terminal extracellular domain).
    Database link: O75473

  • Positive control

    • IHC-P: Human pancreas, islets tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab219107 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/400.

Target

  • Function

    Orphan receptor. Stem cell marker of the intestinal epithelium and the hair follicule. Target gene of Wnt signaling.
  • Tissue specificity

    Expressed in skeletal muscle, placenta, spinal cord, and various region of brain. Expressed at the base of crypts in colonic and small mucosa stem cells. In premalignant cancer expression is not restricted to the cript base. Overexpressed in cancers of the ovary, colon and liver.
  • Sequence similarities

    Belongs to the G-protein coupled receptor 1 family.
    Contains 16 LRR (leucine-rich) repeats.
    Contains 1 LRRNT domain.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • FEX antibody
    • G protein coupled receptor 49 antibody
    • G protein coupled receptor 67 antibody
    • g protein-coupled receptor fex antibody
    • G-protein coupled receptor 49 antibody
    • G-protein coupled receptor 67 antibody
    • G-protein coupled receptor HG38 antibody
    • GPCR GPR49 antibody
    • GPR 49 antibody
    • GPR 67 antibody
    • GPR49 antibody
    • GPR67 antibody
    • GRP 49 antibody
    • GRP49 antibody
    • HG 38 antibody
    • HG38 antibody
    • Leucine rich repeat containing G protein coupled receptor 5 antibody
    • Leucine-rich repeat-containing G-protein coupled receptor 5 antibody
    • LGR 5 antibody
    • LGR5 antibody
    • LGR5_HUMAN antibody
    • MGC117008 antibody
    • Orphan G protein coupled receptor HG38 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded human pancreas, islets tissue labeling LGR5 with ab219107 at 1/400 dilution.

References

ab219107 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

Application
Western blot
Sample
Bos taurus Cell lysate - other (ephitelial oviductal cells)
Gel Running Conditions
Reduced Denaturing (8%)
Loading amount
30 µg
Specification
ephitelial oviductal cells
Blocking step
Milk as blocking agent for 1 hour(s) and 0 minute(s) · Concentration: 5% · Temperature: RT°C

Abcam user community

Verified customer

Submitted Jun 28 2018

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