Anti-LGR5 antibody (ab75732)

Rabbit polyclonal LGR5 antibody. Validated in WB, ELISA, IHC, Flow Cyt, ICC/IF and tested in Mouse, Human. Cited in 23 publication(s). Independently reviewed in 15 review(s).

Publishing research using ab75732? Please let us know so that we can cite the reference in this datasheet.

ab75732 has been referenced in 24 publications.

  • Chen Z & Xue C G-Protein-Coupled Receptor 5 (LGR5) Overexpression Activates ß-Catenin Signaling in Breast Cancer Cells via Protein Kinase A. Med Sci Monit Basic Res 25:15-25 (2019). PubMed: 30662060
  • Saito Y  et al. Induction of differentiation of intrahepatic cholangiocarcinoma cells to functional hepatocytes using an organoid culture system. Sci Rep 8:2821 (2018). PubMed: 29434290
  • Sun ZJ  et al. A fusion protein composed of the DSL domain of Dll1 and RGD motif protects cryptic stem cells in irradiation injury. Biosci Rep 38:N/A (2018). PubMed: 29444821
  • Wu V  et al. ALDH1A1 positive cells are a unique component of the tonsillar crypt niche and are lost along with NGFR positive stem cells during tumourigenesis. Pathology N/A:N/A (2018). WB . PubMed: 29891189
  • Tanaka K  et al. DEAD box protein DDX1 promotes colorectal tumorigenesis through transcriptional activation of the LGR5 gene. Cancer Sci 109:2479-2489 (2018). PubMed: 29869821
  • Carmon KS  et al. LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1-Rac1 pathway. J Biol Chem 292:14989-15001 (2017). PubMed: 28739799
  • Srinivasan T  et al. NOTCH Signaling Regulates Asymmetric Cell Fate of Fast- and Slow-Cycling Colon Cancer-Initiating Cells. Cancer Res 76:3411-21 (2016). PubMed: 27197180
  • Feng S  et al. Proton pump inhibitor pantoprazole inhibits the proliferation, self-renewal and chemoresistance of gastric cancer stem cells via the EMT/ß-catenin pathways. Oncol Rep 36:3207-3214 (2016). PubMed: 27748935
  • Podany AB  et al. ZnT2-Mediated Zinc Import Into Paneth Cell Granules Is Necessary for Coordinated Secretion and Paneth Cell Function in Mice. Cell Mol Gastroenterol Hepatol 2:369-383 (2016). PubMed: 28174721
  • Sun G  et al. Inhibitory effects of Hedyotis diffusa Willd. on colorectal cancer stem cells. Oncol Lett 11:3875-3881 (2016). WB ; Human . PubMed: 27313710
  • Gong X  et al. LGR5-Targeted Antibody-Drug Conjugate Eradicates Gastrointestinal Tumors and Prevents Recurrence. Mol Cancer Ther 15:1580-90 (2016). PubMed: 27207778
  • Yin L  et al. An amino acid-based oral rehydration solution (AA-ORS) enhanced intestinal epithelial proliferation in mice exposed to radiation. Sci Rep 6:37220 (2016). IHC ; Mouse . PubMed: 27876791
  • Nakashima H  et al. R-spondin 2 promotes acetylcholine receptor clustering at the neuromuscular junction via Lgr5. Sci Rep 6:28512 (2016). PubMed: 27328992
  • Choi YJ  et al. Expression of Leucine-rich Repeat-containing G-protein Coupled Receptor 5 and CD44: Potential Implications for Gastric Cancer Stem Cell Marker. J Cancer Prev 21:279-287 (2016). PubMed: 28053963
  • Kitamura J  et al. Chronic lung injury by constitutive expression of activation-induced cytidine deaminase leads to focal mucous cell metaplasia and cancer. PLoS One 10:e0117986 (2015). IHC ; Mouse . PubMed: 25659078
  • Shaikh LH  et al. LGR5 Activates Noncanonical Wnt Signaling and Inhibits Aldosterone Production in the Human Adrenal. J Clin Endocrinol Metab 100:E836-44 (2015). IHC ; Human . PubMed: 25915569
  • Curcio C  et al. The expression of LGR5 in healthy human stem cell niches and its modulation in inflamed conditions. Mol Vis 21:644-8 (2015). PubMed: 26097379
  • Distler A  et al. Combined inhibition of morphogen pathways demonstrates additive antifibrotic effects and improved tolerability. Ann Rheum Dis N/A:N/A (2014). Human . PubMed: 24445254
  • Wang D  et al. Knockdown of LGR5 suppresses the proliferation of glioma cells in vitro and in vivo. Oncol Rep 31:41-9 (2014). IHC-P ; Human . PubMed: 24172981
  • Kim JH  et al. Distinctive genetic activity pattern of the human dental pulp between deciduous and permanent teeth. PLoS One 9:e102893 (2014). IHC-P ; Human . PubMed: 25047033
  • Ko SB  et al. Inflammation increases cells expressing ZSCAN4 and progenitor cell markers in the adult pancreas. Am J Physiol Gastrointest Liver Physiol 304:G1103-16 (2013). IF, IHC . PubMed: 23599043
  • Simon E  et al. The spatial distribution of LGR5+ cells correlates with gastric cancer progression. PLoS One 7:e35486 (2012). IHC-P ; Human . PubMed: 22530031
  • Mardaryev AN  et al. Lhx2 differentially regulates Sox9, Tcf4 and Lgr5 in hair follicle stem cells to promote epidermal regeneration after injury. Development 138:4843-52 (2011). PubMed: 22028024
  • Fan XS  et al. Expression of Lgr5 in human colorectal carcinogenesis and its potential correlation with beta-catenin. Int J Colorectal Dis 25:583-90 (2010). Human . PubMed: 20195621

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