Licarbazepine (10,11-Dihydro-10-hydroxycarbamazepine), Active oxcarbazepine metabolite (ab145867)

Overview

  • Product name

    Licarbazepine (10,11-Dihydro-10-hydroxycarbamazepine), Active oxcarbazepine metabolite
  • Description

    Active oxcarbazepine metabolite
  • Alternative names

    • 10,11-Dihydro-10-hydroxycarbamazepine
  • Biological description

    Active metabolite of oxcarbazepine (ab141827). Induces microsomal enzymes via sodium channel protein inhibition. Potentiates minor GABAA receptor currents; exhibits anticonvulsant activity. Antiepileptic agent. Active in vivo.
  • Purity

    > 99%
  • CAS Number

    29331-92-8
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    10,11-Dihydro-10-hydroxy-5H-dibenz[b,f]azepine-5-carboxamide
  • Molecular weight

    254.28
  • Molecular formula

    C15H14N2O2
  • PubChem identifier

    114709
  • Storage instructions

    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in ethanol to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1C(C2=CC=CC=C2N(C3=CC=CC=C31)C(=O)N)O
  • Source

    Synthetic

References

This product has been referenced in:

  • Souppart C  et al. Pharmacokinetics of licarbazepine in healthy volunteers: single and multiple oral doses and effect of food. J Clin Pharmacol 48:563-9 (2008). Read more (PubMed: 18258749) »
  • Mazza M  et al. Oxcarbazepine in bipolar disorder: a critical review of the literature. Expert Opin Pharmacother 8:649-56 (2007). Read more (PubMed: 17376019) »
  • Benes J  et al. Anticonvulsant and sodium channel-blocking properties of novel 10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxamide derivatives. J Med Chem 42:2582-7 (1999). Read more (PubMed: 10411478) »

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