Lifitegrast, LFA-1 (lymphocyte function-associated antigen-1) antagonist (ab235456)

Overview

  • Product name

    Lifitegrast, LFA-1 (lymphocyte function-associated antigen-1) antagonist
  • Description

    LFA-1 (lymphocyte function-associated antigen-1) antagonist
  • Alternative names

    • SAR-1118
    • SAR1118
    • Xiidra
  • Biological description

    LFA-1 (lymphocyte function-associated antigen-1) antagonist intended for the treatment of vascular complications of the eye. Lifitegrast is a novel T-cell integrin antagonist that is designed to mimic the binding epitope of ICAM-1. It acts as a molecular decoy to block the LFA-1/ICAM-1 interaction and thus inhibits downstream inflammatory responses.

  • Purity

    > 98%
  • CAS Number

    1025967-78-5
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxamido)-3-(3-(methylsulfonyl)phenyl)propanoic acid

  • Molecular weight

    615.48
  • Molecular formula

    C29H24Cl2N2O7S
  • PubChem identifier

    335987004
  • Storage instructions

    Shipped at Room Temperature. Store at -20°C. Store In the Dark. Store under desiccating conditions.
  • Solubility overview

    DMSO >30 mg/mL

    Ethanol 20 mg/mL

    Insoluble in water

  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CS(=O)(=O)C1=CC=CC(=C1)CC(C(=O)O)NC(=O)C2=C(C=C3CN(CCC3=C2Cl)C(=O)C4=CC5=C(C=C4)C=CO5)Cl
  • Source

    Synthetic

References

This product has been referenced in:

  • Zhong M  et al. Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye. ACS Med Chem Lett 3:203-6 (2012). Read more (PubMed: 24900456) »
  • Gadek TR  et al. Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule. Science 295:1086-9 (2002). Read more (PubMed: 11834839) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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