Product nameLifitegrast, LFA-1 (lymphocyte function-associated antigen-1) antagonist
DescriptionLFA-1 (lymphocyte function-associated antigen-1) antagonist
LFA-1 (lymphocyte function-associated antigen-1) antagonist intended for the treatment of vascular complications of the eye. Lifitegrast is a novel T-cell integrin antagonist that is designed to mimic the binding epitope of ICAM-1. It acts as a molecular decoy to block the LFA-1/ICAM-1 interaction and thus inhibits downstream inflammatory responses.
Storage instructionsShipped at Room Temperature. Store at -20°C. Store In the Dark. Store under desiccating conditions.
DMSO >30 mg/mL
Ethanol 20 mg/mL
Insoluble in water
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
This product has been referenced in:
- Zhong M et al. Discovery and Development of Potent LFA-1/ICAM-1 Antagonist SAR 1118 as an Ophthalmic Solution for Treating Dry Eye. ACS Med Chem Lett 3:203-6 (2012). Read more (PubMed: 24900456) »
- Gadek TR et al. Generation of an LFA-1 antagonist by the transfer of the ICAM-1 immunoregulatory epitope to a small molecule. Science 295:1086-9 (2002). Read more (PubMed: 11834839) »