Anti-LILRB1 antibody [HP-F1] - Low endotoxin, Azide free (ab185796)

Overview

  • Product name

    Anti-LILRB1 antibody [HP-F1] - Low endotoxin, Azide free
    See all LILRB1 primary antibodies
  • Description

    Mouse monoclonal [HP-F1] to LILRB1 - Low endotoxin, Azide free
  • Host species

    Mouse
  • Tested applications

    Suitable for: Functional Studies, Flow Cytmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    The details of the immunogen for this antibody are not available.

  • Positive control

    • Normal Human peripheral cells.
  • General notes

    Endotoxin: Less than 0.001 ng/ug antibody, as determined by the LAL assay.

    The monoclonal antibody HP-F1 has been shown to reduce the amount of CD16-dependent cytolytic activity of functional NK cells.

Properties

  • Form

    Liquid
  • Storage instructions

    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer

    pH: 7.2
    Constituent: PBS

    Aqueous buffer.
  • Concentration information loading...
  • Purity

    Protein G purified
  • Clonality

    Monoclonal
  • Clone number

    HP-F1
  • Isotype

    IgG1
  • Light chain type

    kappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab185796 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Functional Studies Use at an assay dependent concentration.
Flow Cyt Use 0.125µg for 105-8 cells.

In a final volume of 100 μL.

 

 

 

 

ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

 

Target

  • Function

    Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
  • Tissue specificity

    Expressed predominantly on B-cells and monocytes, and at lower levels on dendritic cells. Detected on a low percentage of T-cells and natural killer (NK) cells.
  • Sequence similarities

    Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
  • Domain

    Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.
  • Post-translational
    modifications

    Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.
  • Cellular localization

    Membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • CD85 antibody
    • CD85 antigen antibody
    • CD85 antigen like family member J antibody
    • CD85 antigen-like family member J antibody
    • CD85j antibody
    • CD85j antigen antibody
    • Ig like transcript 2 antibody
    • ILT 2 antibody
    • ILT-2 antibody
    • ILT2 antibody
    • immunoglobulin like transcript 2 antibody
    • Immunoglobulin-like transcript 2 antibody
    • leukocyte Ig like receptor 1 antibody
    • Leukocyte immunoglobulin like receptor 1 antibody
    • leukocyte immunoglobulin like receptor subfamily B member 1 antibody
    • Leukocyte immunoglobulin like receptor subfamily B member 1 precursor antibody
    • leukocyte immunoglobulin like receptor subfamily B member 1 soluble isoform antibody
    • leukocyte immunoglobulin like receptor, subfamily B, member 1 antibody
    • Leukocyte immunoglobulin-like receptor 1 antibody
    • Leukocyte immunoglobulin-like receptor subfamily B member 1 antibody
    • leukocyte immunoglobulin-like receptor subfamily B member 1 soluble isoform antibody
    • leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 antibody
    • LILRB1 antibody
    • LIR 1 antibody
    • LIR-1 antibody
    • LIR1 antibody
    • LIRB1_HUMAN antibody
    • MIR 7 antibody
    • MIR-7 antibody
    • MIR7 antibody
    • Monocyte/macrophage immunoglobulin like receptor 7 antibody
    • Monocyte/macrophage immunoglobulin-like receptor 7 antibody
    • PIR B antibody
    • PIRB antibody
    see all

References

ab185796 has not yet been referenced specifically in any publications.

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