• Product name
  • Description
    Goat polyclonal to LIN7B
  • Host species
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat
    Predicted to work with: Cow, Dog, Human, Pig
  • Immunogen

    Synthetic peptide:


    , corresponding to N terminal amino acids 2-15 of Human LIN7B.

  • Positive control
    • Mouse or Rat brain
  • General notes
    GenBank Accession Number – NP_071448.


  • Form
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Purification notes
    Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • Clonality
  • Isotype
  • Research areas


Our Abpromise guarantee covers the use of ab5967 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.5 - 2 µg/ml. Detects a band of approximately 25 kDa (predicted molecular weight: 23 kDa).


  • Function
    Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells. May increase the amplitude of ACCN3 acid-evoked currents by stabilizing the channel at the cell surface.
  • Sequence similarities
    Belongs to the lin-7 family.
    Contains 1 L27 domain.
    Contains 1 PDZ (DHR) domain.
  • Domain
    The kinase interacting site is required for proper delivery of ERBB2 to the basolateral membrane.
    The PDZ domain regulates endocytosis and recycling of the receptor at the membrane.
    The L27 domain mediates interaction with CASK and is involved in the formation of multimeric complexes and the association of LIN7 to membranes.
  • Cellular localization
    Cell membrane. Basolateral cell membrane. Cell junction. Cell junction > synapse > postsynaptic cell membrane > postsynaptic density. Cell junction > tight junction. Cell junction > synapse > synaptosome. Enriched in synaptosomes and at epithelial cell-cell junctions (By similarity). Mainly basolateral in renal epithelial cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • hVeli2 antibody
    • hLin7B antibody
    • hVeli2 antibody
    • Lin 7 homolog B C elegans antibody
    • LIN 7B antibody
    • Lin 7b protein likely ortholog of mouse LIN 7B mammalian LIN 7 protein 2 antibody
    • Lin-7B antibody
    • LIN7B antibody
    • LIN7B_HUMAN antibody
    • MALS 2 antibody
    • MALS-2 antibody
    • MALS2 antibody
    • Mammalian lin seven protein 2 antibody
    • Mammalian lin-seven protein 2 antibody
    • Protein lin 7 homolog B antibody
    • Protein lin-7 homolog B antibody
    • VELI 2 antibody
    • Veli-2 antibody
    • VELI2 antibody
    • Vertebrate lin 7 homolog 2 antibody
    • Vertebrate lin-7 homolog 2 antibody
    see all



This product has been referenced in:
  • Zucker B  et al. Decreased Lin7b expression in layer 5 pyramidal neurons may contribute to impaired corticostriatal connectivity in huntington disease. J Neuropathol Exp Neurol 69:880-95 (2010). Read more (PubMed: 20720508) »
See 1 Publication for this product

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