Overview

  • Product name

    Linezolid, Protein synthesis inhibitor
  • Description

    Protein synthesis inhibitor. Potent oxazolidinone antibiotic.
  • Biological description

    Protein synthesis inhibitor. Inhibits bacterial translation by preventing the formation of the tRNAfMet-mRNA-70S (or 30S) subunit ternary complex. Potent synthetic antibiotic active against a variety of multi-drug resistant gram-positive bacteria in vitro and in vivo. Member of the oxazolidinone class of drugs.
  • Purity

    > 99%
  • CAS Number

    165800-03-3
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N-[[(5S)-3-(3-Fluoro-4-morpholin-4-ylphenyl)-2-oxo-1,3-oxazolidin-5-yl]methyl]acetamide
  • Molecular weight

    337.35
  • Molecular formula

    C16H20FN3O4
  • PubChem identifier

    441401
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in DMSO to 100 mM and in ethanol to 25 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    CC(=O)NCC1CN(C(=O)O1)C2=CC(=C(C=C2)N3CCOCC3)F
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Keel RA  et al. Pharmacokinetics and pulmonary disposition of tedizolid and linezolid in a murine pneumonia model under variable conditions. Antimicrob Agents Chemother 56:3420-2 (2012). Read more (PubMed: 22430966) »
  • Brickner SJ  et al. Linezolid (ZYVOX), the first member of a completely new class of antibacterial agents for treatment of serious gram-positive infections. J Med Chem 51:1981-90 (2008). Read more (PubMed: 18338841) »
  • Ford CW  et al. In vivo activities of U-100592 and U-100766, novel oxazolidinone antimicrobial agents, against experimental bacterial infections. Antimicrob Agents Chemother 40:1508-13 (1996). Read more (PubMed: 8726028) »

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