Key features and details
- Rabbit polyclonal to Lingo1
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
Product nameAnti-Lingo1 antibody
See all Lingo1 primary antibodies
DescriptionRabbit polyclonal to Lingo1
Tested applicationsSuitable for: WBmore details
Species reactivityReacts with: Human
Predicted to work with: Mouse, Rat, Chicken
Recombinant fragment corresponding to a region within amino acids 364-586 of Human Lingo1 (UniProt Q96FE5).
- MCF7 whole cell lysate; NT2D1, IMR32 and U87-MG cell lysates
Storage instructionsShipped at 4°C. Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle.
Storage bufferpH: 7.00
Preservative: 0.025% Proclin 300
Constituents: PBS, 1% BSA, 20% Glycerol
Concentration information loading...
PurityImmunogen affinity purified
Our Abpromise guarantee covers the use of ab127000 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
|WB||1/500 - 1/3000. Predicted molecular weight: 70 kDa.|
FunctionFunctional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development.
Tissue specificityExpressed exclusively in the central nervous system. Highest level in the in amygdala, hippocampus, thalamus and cerebral cortex. In the rest of the brain a basal expression seems to be always present. Up-regulated in substantia nigra neurons from Parkinson disease patients.
Sequence similaritiesContains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 11 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain.
modificationsN-glycosylated. Contains predominantly high-mannose glycans.
Cellular localizationCell membrane.
- Information by UniProt
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ab127000 has not yet been referenced specifically in any publications.