Overview

  • Product name

    Anti-Lingo1 antibody - C-terminal
    See all Lingo1 primary antibodies
  • Description

    Rabbit polyclonal to Lingo1 - C-terminal
  • Host species

    Rabbit
  • Specificity

    BLAST analysis of the peptide immunogen showed no homology with other Human proteins.
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Chicken, Cow, Turkey, Pig, Gorilla, Opossum, Common marmoset, Orangutan
  • Immunogen

    Synthetic peptide, containing 16 amino acids, from the C-terminal region of Human Lingo1.

  • Positive control

    • Human brain (hippocampus) tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab140819 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 µg/ml. Perform heat mediated antigen retrieval before commencing with IHC staining protocol.

Target

  • Function

    Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development.
  • Tissue specificity

    Expressed exclusively in the central nervous system. Highest level in the in amygdala, hippocampus, thalamus and cerebral cortex. In the rest of the brain a basal expression seems to be always present. Up-regulated in substantia nigra neurons from Parkinson disease patients.
  • Sequence similarities

    Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
    Contains 11 LRR (leucine-rich) repeats.
    Contains 1 LRRCT domain.
    Contains 1 LRRNT domain.
  • Post-translational
    modifications

    N-glycosylated. Contains predominantly high-mannose glycans.
  • Cellular localization

    Cell membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • FLJ14594 antibody
    • LERN 1 antibody
    • LERN1 antibody
    • Leucine rich repeat and Ig domain containing 1 antibody
    • Leucine rich repeat neuronal 6A antibody
    • Leucine rich repeat neuronal protein 1 antibody
    • Leucine rich repeat neuronal protein 6A antibody
    • Leucine-rich repeat and immunoglobilin domain-containing protein 1 antibody
    • Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 antibody
    • Leucine-rich repeat neuronal protein 1 antibody
    • Leucine-rich repeat neuronal protein 6A antibody
    • LIGO1_HUMAN antibody
    • Lingo 1 antibody
    • LINGO1 antibody
    • LRR and Ig domain containing Nogo Receptor interating protein antibody
    • Lrrn 6a antibody
    • Lrrn6a antibody
    • Lrrn6a protein antibody
    • MGC17422 antibody
    • Nogo Receptor interacting protein antibody
    • PRO227 antibody
    • UNQ201 antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human brain (hippocampus) tissue labelling Lingo1 with ab140819 at 5 ug/ml.

References

ab140819 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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