Linopirdine dihydrochloride, M-type K+ current blocker (ab145548)

Overview

  • Product name

    Linopirdine dihydrochloride, M-type K+ current blocker
  • Description

    M-type K+ current blocker
  • Biological description

    M-type K+ current blocker (IC50 = 2.4 μM). Water soluble Linopirdine (ab145564) derivative. Neurotransmitter release enhancer. Increases brain acetylcholine release. TRPV1 agonist. Shows cognitive enhancing effects in vivo. Orally active.
  • Purity

    > 98%
  • CAS Number

    113168-57-3
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Stott JB  et al. Contribution of Kv7 Channels to Natriuretic Peptide Mediated Vasodilation in Normal and Hypertensive Rats. Hypertension : (2014). Read more (PubMed: 25547342) »
  • Neacsu C & Babes A The M-channel blocker linopirdine is an agonist of the capsaicin receptor TRPV1. J Pharmacol Sci 114:332-40 (2010). Read more (PubMed: 21099148) »
  • Wickenden AD  et al. N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator. Mol Pharmacol 73:977-86 (2008). Read more (PubMed: 18089837) »

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