Key features and details
- M-type K+ current blocker
- CAS Number: 105431-72-9
- Purity: > 98%
- Soluble in ethanol to 100 mM and in DMSO to 25 mM
- Form / State: Solid
- Source: Synthetic
Product nameLinopirdine (DuP-996), M-type K+ current blocker
DescriptionM-type K+ current blocker
Biological descriptionM-type K+ current blocker (IC50 = 2.4 μM). Neurotransmitter release enhancer. Increases brain acetylcholine release. TRPV1 agonist. Shows cognitive enhancing effects in vivo. Water soluble derivative (ab145548) also available.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in ethanol to 100 mM and in DMSO to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Signal transduction
- Inositol & cAMP signaling
- Adenylyl cyclase
- Receptors & Transporters
- Benzodiazepine Site
- Antagonists / inverse agonists
- Pathways and Processes
- Metabolic signaling pathways
- Lipid and lipoprotein metabolism
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab145564 has not yet been referenced specifically in any publications.