Linopirdine (DuP-996), M-type K+ current blocker (ab145564)

Overview

  • Product name

    Linopirdine (DuP-996), M-type K+ current blocker
  • Description

    M-type K+ current blocker
  • Alternative names

    • DuP-996
  • Biological description

    M-type K+ current blocker (IC50 = 2.4 μM). Neurotransmitter release enhancer. Increases brain acetylcholine release. TRPV1 agonist. Shows cognitive enhancing effects in vivo. Water soluble derivative (ab145548) also available.
  • Purity

    > 98%
  • CAS Number

    105431-72-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Neacsu C & Babes A The M-channel blocker linopirdine is an agonist of the capsaicin receptor TRPV1. J Pharmacol Sci 114:332-40 (2010). Read more (PubMed: 21099148) »
  • Zaczek R  et al. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J Pharmacol Exp Ther 285:724-30 (1998). Read more (PubMed: 9580619) »
  • Schnee ME & Brown BS Selectivity of linopirdine (DuP 996), a neurotransmitter release enhancer, in blocking voltage-dependent and calcium-activated potassium currents in hippocampal neurons. J Pharmacol Exp Ther 286:709-17 (1998). Read more (PubMed: 9694925) »

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