Product nameLinopirdine (DuP-996), M-type K+ current blocker
DescriptionM-type K+ current blocker
Biological descriptionM-type K+ current blocker (IC50 = 2.4 μM). Neurotransmitter release enhancer. Increases brain acetylcholine release. TRPV1 agonist. Shows cognitive enhancing effects in vivo. Water soluble derivative (ab145548) also available.
Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in ethanol to 100 mM and in DMSO to 25 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Signal transduction
- Inositol & cAMP signaling
- Adenylyl cyclase
This product has been referenced in:
- Neacsu C & Babes A The M-channel blocker linopirdine is an agonist of the capsaicin receptor TRPV1. J Pharmacol Sci 114:332-40 (2010). Read more (PubMed: 21099148) »
- Zaczek R et al. Two new potent neurotransmitter release enhancers, 10,10-bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J Pharmacol Exp Ther 285:724-30 (1998). Read more (PubMed: 9580619) »
- Schnee ME & Brown BS Selectivity of linopirdine (DuP 996), a neurotransmitter release enhancer, in blocking voltage-dependent and calcium-activated potassium currents in hippocampal neurons. J Pharmacol Exp Ther 286:709-17 (1998). Read more (PubMed: 9694925) »