Anti-LIPA3 antibody - C-terminal (ab180888)

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Key features and details

  • Rabbit polyclonal to LIPA3 - C-terminal
  • Suitable for: WB
  • Reacts with: Mouse, Rat, Human
  • Isotype: IgG

Overview

  • Product name

    Anti-LIPA3 antibody - C-terminal

  • Description

    Rabbit polyclonal to LIPA3 - C-terminal

  • Host species

    Rabbit

  • Tested applications

    Suitable for: WBmore details

  • Species reactivity

    Reacts with: Mouse, Rat, Human

  • Immunogen

    Synthetic peptide corresponding to Human LIPA3 (C terminal). (17 amino acid peptide; NP_003651).
    Database link: O75145

  • Positive control

    • 293 cell lysate.

  • General notes

    Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.

    Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.

    We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.

    In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.

    We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.

    Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.

    Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.

Properties

Applications

Our Abpromise guarantee covers the use of ab180888 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 131 kDa (predicted molecular weight: 133 kDa).

Target

  • Function

    May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.

  • Tissue specificity

    Expressed only in brain.

  • Sequence similarities

    Belongs to the liprin family. Liprin-alpha subfamily.
    Contains 3 SAM (sterile alpha motif) domains.

  • Domain

    The N-terminal coiled coil regions mediate homodimerization preferentially and heterodimerization type alpha/alpha. The C-terminal, non-coiled coil regions mediate heterodimerization type alpha/beta and interaction with PTPRD, PTPRF and PTPRS.

  • Cellular localization

    Cytoplasm. Cell surface. Colocalizes with PTPRF at the cell surface.
  • Information by UniProt

  • Database links

    see all

  • Alternative names

    • LIPA3_HUMAN antibody
    • liprin antibody
    • Liprin-alpha-3 antibody
    • LPNA3 antibody
    • Ppfia3 antibody
    • Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3 antibody
    • protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 antibody
    • protein tyrosine phosphatase, receptor type, f polypeptide, alpha 3 antibody
    • PTPRF-interacting protein alpha-3 antibody
    see all

Images

  • Western blot - Anti-LIPA3 antibody - C-terminal (ab180888)
    Western blot - Anti-LIPA3 antibody - C-terminal (ab180888)
    Lane 1 : Anti-LIPA3 antibody - C-terminal (ab180888) at 1 µg/ml
    Lane 2 : Anti-LIPA3 antibody - C-terminal (ab180888) at 2 µg/ml

    All lanes : 293 cell lysate

    Lysates/proteins at 15 µg per lane.

    Predicted band size: 133 kDa
    Observed band size: 131 kDa
    why is the actual band size different from the predicted?

References (0)

Publishing research using ab180888? Please let us know so that we can cite the reference in this datasheet.

ab180888 has not yet been referenced specifically in any publications.

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