• Product name
  • Description
    Rabbit polyclonal to Lipin 1
  • Host species
  • Tested applications
    Suitable for: IHC-P, WB, ICC/IFmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human Lipin 1 (C terminal). The exact sequence is proprietary. 18 amino acids.
    Database link: Q14693

  • Positive control
    • K562 cell lysate. Human small intestine tissue.



Our Abpromise guarantee covers the use of ab181389 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P Use a concentration of 5 µg/ml.
WB Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 125 kDa (predicted molecular weight: 99 kDa).
ICC/IF Use a concentration of 20 µg/ml.


  • Function
    Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A/PPARA to modulate lipid metabolism gene expression (By similarity). Is involved in adipocyte differentiation. May also be involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol.
  • Tissue specificity
    Abundant in adipose tissue and skeletal muscle. Lower levels in some portions of the digestive tract.
  • Involvement in disease
    Defects in LPIN1 are a cause of autosomal recessive acute recurrent myoglobinuria (ARARM) [MIM:268200]; also known as acute recurrent rhabdomyolysis. Recurrent myoglobinuria is characterized by recurrent attacks of rhabdomyolysis (necrosis or disintegration of skeletal muscle) associated with muscle pain and weakness and followed by excretion of myoglobin in the urine. Renal failure may occasionally occur. Onset is usually in early childhood under the age of 5 years.
  • Sequence similarities
    Belongs to the lipin family.
  • Domain
    Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL), a transcriptional binding motif, which mediates interaction with PPARA.
    Contains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif essential for phosphatidate phosphatase activity.
  • Post-translational
    Phosphorylated at multiple sites in response to insulin. Phosphorylation is controlled by the mTOR signaling pathway (By similarity). Dephosphorylated in response to epinephrine and oleic acid.
  • Cellular localization
    Nucleus. Cytoplasm > cytosol. Endoplasmic reticulum membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • EC= antibody
    • KIAA0188 antibody
    • Lipin-1 antibody
    • Lpin1 antibody
    • LPIN1_HUMAN antibody
    • PAP1 antibody
    • Phosphatidate phosphatase LPIN1 antibody
    see all


  • Anti-Lipin 1 antibody (ab181389) at 1 µg/ml + K562 whole cell lysate at 15 µg

    Predicted band size: 99 kDa
    Observed band size: 125 kDa
    why is the actual band size different from the predicted?

  • Immunohistochemical analysis of Human small intestine tissue, staining Lipin 1 with ab181389 at 5 μg/ml.

  • Immunfluorescence analysis of Human small intestine tissue, staining Lipin 1 with ab181389 at 20 μg/ml.


This product has been referenced in:
See all 2 Publications for this product

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