• Product name

    Anti-Lipin 2/LPIN2 antibody [EPR12479]
    See all Lipin 2/LPIN2 primary antibodies
  • Description

    Rabbit monoclonal [EPR12479] to Lipin 2/LPIN2
  • Host species

  • Tested applications

    Suitable for: WB, Flow Cytmore details
    Unsuitable for: ICC/IF,IHC-P or IP
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide within Human Lipin 2/LPIN2 aa 850 to the C-terminus (C terminal). The exact sequence is proprietary.
    Database link: Q92539

  • Positive control

    • WB: Jurkat, HepG2, 293T and HeLa whole cell lysate (ab150035). Flow Cyt: Jurkat cells.
  • General notes

    Protein previously labeled as Lipin 2.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.

    This product is a recombinant rabbit monoclonal antibody.



Our Abpromise guarantee covers the use of ab176347 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/10000. Predicted molecular weight: 99 kDa.
Flow Cyt 1/10 - 1/100.

ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.


  • Application notes
    Is unsuitable for ICC/IF,IHC-P or IP.
  • Target

    • Function

      Plays important roles in controlling the metabolism of fatty acids at differents levels. Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis in the reticulum endoplasmic membrane. Acts also as a nuclear transcriptional coactivator for PPARGC1A to modulate lipid metabolism.
    • Tissue specificity

      Expressed in liver, lung, kidney, placenta, spleen, thymus, lymph node, prostate, testes, small intestine, and colon.
    • Involvement in disease

      Defects in LPIN2 are the cause of Majeed syndrome (MAJEEDS) [MIM:609628]. An autosomal recessive syndrome characterized by chronic recurrent multifocal osteomyelitis that is of early onset with a lifelong course, congenital dyserythropoietic anemia that presents as hypochromic, microcytic anemia during the first year of life and ranges from mild to transfusion-dependent, and transient inflammatory dermatosis, often manifesting as Sweet syndrome (neutrophilic skin infiltration).
    • Sequence similarities

      Belongs to the lipin family.
    • Domain

      Contains 1 Asp-Xaa-Asp-Xaa-Thr (DXDXT) motif, a catalytic motif known to be essential for phosphatidate phosphatase activity.
      Contains one Leu-Xaa-Xaa-Ile-Leu (LXXIL) motif, a motif known to be a transcriptional binding motif.
    • Cellular localization

      Nucleus. Cytoplasm > cytosol. Endoplasmic reticulum membrane. Translocates to endoplasmic reticulum membrane with increasing levels of oleate.
    • Information by UniProt
    • Database links

    • Alternative names

      • KIAA0249 antibody
      • Lipin-2 antibody
      • Lipin2 antibody
      • LPIN 2 antibody
      • LPIN2 antibody
      • LPIN2_HUMAN antibody
      • OTTHUMP00000162242 antibody
      • Phosphatidate phosphatase LPIN2 antibody
      see all


    • All lanes : Anti-Lipin 2/LPIN2 antibody [EPR12479] (ab176347) at 1/1000 dilution

      Lane 1 : Jurkat cell lysate
      Lane 2 : HepG2 cell lysate
      Lane 3 : 293T cell lysate
      Lane 4 : HeLa cell lysate

      Lysates/proteins at 10 µg per lane.

      Predicted band size: 99 kDa

    • Flow cytometric analysis of permeabilized Jurkat cells labeling Lipin 2/LPIN2 with ab176347 at 1/10 dilution (red) or a rabbit IgG (negative) (green).


    ab176347 has not yet been referenced specifically in any publications.

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