Overview

  • Product name
    Anti-Lipoic Acid antibody
  • Description
    Rabbit polyclonal to Lipoic Acid
  • Host species
    Rabbit
  • Specificity
    Recognizes native lipoic acid and lipoic acid covalently attached to proteins. It does not recognize lipoic acid modified by 4-HNE (4-hydroxy-2-noneal) and other lipid peroxidation products.
  • Tested applications
    Suitable for: WB, IHC-Fr, ELISA, IHC-Pmore details
  • Species reactivity
    Reacts with a broad range of species.
  • Immunogen

    Lipoic acid conjugated to KLH

Properties

Applications

Our Abpromise guarantee covers the use of ab58724 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
IHC-Fr
ELISA
IHC-P
  • Application notes
    ELISA: 1/500 - 1/1000.
    IHC-Fr: 1/50 - 1/500.
    IHC-P: 1/50 - 1/500.
    WB: 1/1000 - 1/10000.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Relevance
      Lipoic acid is a sulfur-containing substance that is readily converted to and from its reduced form, dihydrolipoic acid. It acts as a coenzyme in reactions that occur in the Krebs cycle; specifically it is involved in the decarboxylation of pyruvate and some other alpha-keto acids. Protein-bound lipoic acids such as E2 subunits, a-ketoglutarate dehydrogenase, or pyruvate dehydrogenase have been shown to be highly susceptible to free radical-derived oxidative modification. Lipoic acid is able to deactivate both fat and water soluble free radicals and thereby protect both lipoproteins and membranes; no other anti-oxidant can do this. It has also shown great promise in the treatment of HIV and in diabetes.

    References

    This product has been referenced in:
    • Gong Y  et al. Role of Immune Microenvironmental Factors for Improving the IPI-related Risk Stratification of Aggressive B Cell Lymphoma. Biomed Environ Sci 30:492-500 (2017). WB, ICC/IF ; Human . Read more (PubMed: 28756808) »
    • Habarou F  et al. Biallelic Mutations in LIPT2 Cause a Mitochondrial Lipoylation Defect Associated with Severe Neonatal Encephalopathy. Am J Hum Genet 101:283-290 (2017). Read more (PubMed: 28757203) »
    See all 8 Publications for this product

    Customer reviews and Q&As

    Answer

    Thank you for your enquiry.

    I am sorry to confirm that because we carry over 90,000 products, it is not feasible for us to keep small sample sizes of our products.

    We are happy to reassure our customers that all of our products are covered by our Abpromise, which guarantees that the product will work in the applications and species specified on the datasheet, or we will offer a replacement, credit, or refund within 6 months of purchase. I can confirm that Lipoic Acid antibody (ab58724) is tested and covered by the guarantee in WB.

    If the product is to be used in an untested application not listed on the datasheet, you may be eligible for our AbTrial program if the antibody has not yet been purchased. Please contact ma again by replying to this email prior to purchase for more information. Or you can find more information about this program at the following link:

    www.abcam.com/abtrial

    Otherwise, we like to encourage all of our customers to submit an Abreview via the online product datasheet. We always appreciate customer feedback, whether positive or negative, and we make all product information available to researchers. Plus, each Abreview earns Abpoints that can be used for discounts on future purchases or rewards such as Amazon.com gift certificates.

    To find out more about our Abreview system, please see the following link:

    https://www.abcam.com/abreviews

    I hope this information is helpful. Please do not hesitate to contact us again with any other questions.

    Read More

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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