Product nameAnti-Lipoic Acid antibody
DescriptionRabbit polyclonal to Lipoic Acid
SpecificityRecognizes native lipoic acid and lipoic acid covalently attached to proteins. It does not recognize lipoic acid modified by 4-HNE (4-hydroxy-2-noneal) and other lipid peroxidation products.
Tested applicationsSuitable for: WB, IHC-Fr, ELISA, IHC-Pmore details
Species reactivityReacts with: Species independent
Lipoic acid conjugated to KLH
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferPreservative: None
Constituents: 50% Glycerol, Whole serum, pH 7.5
- Pathways and Processes
- Metabolic signaling pathways
- Energy transfer pathways
- Energy Metabolism
Our Abpromise guarantee covers the use of ab58724 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-Fr: 1/50 - 1/500.
IHC-P: 1/50 - 1/500.
WB: 1/1000 - 1/10000.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
RelevanceLipoic acid is a sulfur-containing substance that is readily converted to and from its reduced form, dihydrolipoic acid. It acts as a coenzyme in reactions that occur in the Krebs cycle; specifically it is involved in the decarboxylation of pyruvate and some other alpha-keto acids. Protein-bound lipoic acids such as E2 subunits, a-ketoglutarate dehydrogenase, or pyruvate dehydrogenase have been shown to be highly susceptible to free radical-derived oxidative modification. Lipoic acid is able to deactivate both fat and water soluble free radicals and thereby protect both lipoproteins and membranes; no other anti-oxidant can do this. It has also shown great promise in the treatment of HIV and in diabetes.
This product has been referenced in:
- Gong Y et al. Role of Immune Microenvironmental Factors for Improving the IPI-related Risk Stratification of Aggressive B Cell Lymphoma. Biomed Environ Sci 30:492-500 (2017). WB, ICC/IF ; Human . Read more (PubMed: 28756808) »
- Habarou F et al. Biallelic Mutations in LIPT2 Cause a Mitochondrial Lipoylation Defect Associated with Severe Neonatal Encephalopathy. Am J Hum Genet 101:283-290 (2017). Read more (PubMed: 28757203) »