Key features and details
- Rabbit polyclonal to Lipoic Acid
- Suitable for: WB, IHC-Fr, ELISA, IHC-P
- Reacts with: Species independent
- Isotype: IgG
Product nameAnti-Lipoic Acid antibody
DescriptionRabbit polyclonal to Lipoic Acid
SpecificityRecognizes native lipoic acid and lipoic acid covalently attached to proteins. It does not recognize lipoic acid modified by 4-HNE (4-hydroxy-2-noneal) and other lipid peroxidation products.
Tested applicationsSuitable for: WB, IHC-Fr, ELISA, IHC-Pmore details
Species reactivityReacts with: Species independent
Lipoic acid conjugated to KLH
Reproducibility is key to advancing scientific discovery and accelerating scientists’ next breakthrough.
Abcam is leading the way with our range of recombinant antibodies, knockout-validated antibodies and knockout cell lines, all of which support improved reproducibility.
We are also planning to innovate the way in which we present recommended applications and species on our product datasheets, so that only applications & species that have been tested in our own labs, our suppliers or by selected trusted collaborators are covered by our Abpromise™ guarantee.
In preparation for this, we have started to update the applications & species that this product is Abpromise guaranteed for.
We are also updating the applications & species that this product has been “predicted to work with,” however this information is not covered by our Abpromise guarantee.
Applications & species from publications and Abreviews that have not been tested in our own labs or in those of our suppliers are not covered by the Abpromise guarantee.
Please check that this product meets your needs before purchasing. If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, as well as customer reviews and Q&As.
Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Storage bufferpH: 7.50
Constituents: Whole serum, 50% Glycerol
Concentration information loading...
- Pathways and Processes
- Metabolic signaling pathways
- Energy transfer pathways
- Energy Metabolism
Our Abpromise guarantee covers the use of ab58724 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
IHC-Fr: 1/50 - 1/500.
IHC-P: 1/50 - 1/500.
WB: 1/1000 - 1/10000.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
RelevanceLipoic acid is a sulfur-containing substance that is readily converted to and from its reduced form, dihydrolipoic acid. It acts as a coenzyme in reactions that occur in the Krebs cycle; specifically it is involved in the decarboxylation of pyruvate and some other alpha-keto acids. Protein-bound lipoic acids such as E2 subunits, a-ketoglutarate dehydrogenase, or pyruvate dehydrogenase have been shown to be highly susceptible to free radical-derived oxidative modification. Lipoic acid is able to deactivate both fat and water soluble free radicals and thereby protect both lipoproteins and membranes; no other anti-oxidant can do this. It has also shown great promise in the treatment of HIV and in diabetes.
ab58724 has been referenced in 12 publications.
- Qian S et al. ATP reduces mitochondrial MECR protein in liver of diet-induced obese mice in mechanism of insulin resistance. Biosci Rep 40:N/A (2020). PubMed: 32440681
- Toshniwal AG et al. ROS Inhibits Cell Growth by Regulating 4EBP and S6K, Independent of TOR, during Development. Dev Cell 49:473-489.e9 (2019). PubMed: 31063760
- Zhang R et al. NDUFAB1 protects against obesity and insulin resistance by enhancing mitochondrial metabolism. FASEB J 33:13310-13322 (2019). PubMed: 31530015
- Gong Y et al. Role of Immune Microenvironmental Factors for Improving the IPI-related Risk Stratification of Aggressive B Cell Lymphoma. Biomed Environ Sci 30:492-500 (2017). WB, ICC/IF ; Human . PubMed: 28756808
- Habarou F et al. Biallelic Mutations in LIPT2 Cause a Mitochondrial Lipoylation Defect Associated with Severe Neonatal Encephalopathy. Am J Hum Genet 101:283-290 (2017). PubMed: 28757203