Overview

  • Product name

    Anti-Lipoprotein lipase antibody [5D2] - BSA and Azide free
    See all Lipoprotein lipase primary antibodies
  • Description

    Mouse monoclonal [5D2] to Lipoprotein lipase - BSA and Azide free
  • Host species

    Mouse
  • Specificity

    ab187848 does not recognise hepatic, pancreatic or related lipases.
  • Tested applications

    Suitable for: WB, ELISA, Inhibition Assay, Flow Cyt, ICC/IFmore details
  • Species reactivity

    Reacts with: Rat, Human, Syrian hamster
    Predicted to work with: CowDoes not react with: Mouse
  • Immunogen

    Full length native protein (purified) corresponding to Cow Lipoprotein lipase aa 1-478. Purified from Cow milk.
    Database link: P11151

Properties

Applications

Our Abpromise guarantee covers the use of ab187848 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use at an assay dependent concentration. Predicted molecular weight: 53 kDa.
ELISA Use at an assay dependent concentration.
Inhibition Assay Use at an assay dependent concentration.
Flow Cyt Use at an assay dependent concentration.

ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.

 

ICC/IF Use at an assay dependent concentration.

Target

  • Function

    The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium.
  • Involvement in disease

    Defects in LPL are the cause of lipoprotein lipase deficiency (LPL deficiency) [MIM:238600]; also known as familial chylomicronemia or hyperlipoproteinemia type I. LPL deficiency chylomicronemia is a recessive disorder usually manifesting in childhood. On a normal diet, patients often present with abdominal pain, hepatosplenomegaly, lipemia retinalis, eruptive xanthomata, and massive hypertriglyceridemia, sometimes complicated with acute pancreatitis.
  • Sequence similarities

    Belongs to the AB hydrolase superfamily. Lipase family.
    Contains 1 PLAT domain.
  • Post-translational
    modifications

    Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.
  • Cellular localization

    Cell membrane. Secreted. Locates to the plasma membrane of microvilli of hepatocytes with triacyl-glycerol-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles.
  • Information by UniProt
  • Database links

  • Alternative names

    • EC 3.1.1 antibody
    • EC 3.1.1.34 antibody
    • HDLCQ11 antibody
    • LIPD antibody
    • LIPL_HUMAN antibody
    • Lipoprotein lipase antibody
    • LPL antibody
    • LPL protein antibody
    • MGC137861 antibody
    see all

References

ab187848 has not yet been referenced specifically in any publications.

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