Overview

  • Product name

    Anti-Lipoprotein lipase antibody
    See all Lipoprotein lipase primary antibodies
  • Description

    Rabbit polyclonal to Lipoprotein lipase
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WBmore details
  • Species reactivity

    Reacts with: Human
    Predicted to work with: Mouse, Rat, Cow, Cat, Pig
  • Immunogen

    A recombinant fragment corresponding to a region within amino acids 134-354 of Human Lipoprotein lipase (UniProt ID: P06858).

  • Positive control

    • A431 whole cell lysate; A431, H1299, HeLa and Molt4 cell lysates

Properties

Applications

Our Abpromise guarantee covers the use of ab137821 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 53 kDa.

Target

  • Function

    The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium.
  • Involvement in disease

    Defects in LPL are the cause of lipoprotein lipase deficiency (LPL deficiency) [MIM:238600]; also known as familial chylomicronemia or hyperlipoproteinemia type I. LPL deficiency chylomicronemia is a recessive disorder usually manifesting in childhood. On a normal diet, patients often present with abdominal pain, hepatosplenomegaly, lipemia retinalis, eruptive xanthomata, and massive hypertriglyceridemia, sometimes complicated with acute pancreatitis.
  • Sequence similarities

    Belongs to the AB hydrolase superfamily. Lipase family.
    Contains 1 PLAT domain.
  • Post-translational
    modifications

    Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.
  • Cellular localization

    Cell membrane. Secreted. Locates to the plasma membrane of microvilli of hepatocytes with triacyl-glycerol-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles.
  • Information by UniProt
  • Database links

  • Alternative names

    • EC 3.1.1 antibody
    • EC 3.1.1.34 antibody
    • HDLCQ11 antibody
    • LIPD antibody
    • LIPL_HUMAN antibody
    • Lipoprotein lipase antibody
    • LPL antibody
    • LPL protein antibody
    • MGC137861 antibody
    see all

Images

  • Anti-Lipoprotein lipase antibody (ab137821) at 1/1000 dilution + A431 whole cell lysate at 30 µg

    Predicted band size: 53 kDa



    10% SDS PAGE

References

This product has been referenced in:

  • Cai H  et al. The Mechanisms of Bushen-Yizhi Formula as a Therapeutic Agent against Alzheimer's Disease. Sci Rep 8:3104 (2018). Read more (PubMed: 29449587) »
  • Teich T  et al. Glucocorticoid antagonism limits adiposity rebound and glucose intolerance in young male rats following the cessation of daily exercise and caloric restriction. Am J Physiol Endocrinol Metab 311:E56-68 (2016). Read more (PubMed: 27143556) »
See all 2 Publications for this product

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