Overview

  • Product name

    Lisinopril dihydrate, ACE inhibitor
  • Description

    Potent, competitive ACE inhibitor
  • Biological description

    Potent, competitive angiotensin converting enzyme inhibitor (IC50 = 4 nM). Cardiotonic and antihypertensive effects. Orally active. Poor blood-brain barrier permeability. Active in vitro and in vivo.
  • Purity

    > 98%
  • CAS Number

    83915-83-7
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    (2S)-1-[(2S)-6-Amino-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]hexanoyl]pyrrolidine-2-carboxylic acid dihydrate
  • Molecular weight

    441.52
  • Molecular formula

    C21H31N3O5.2H2O
  • PubChem identifier

    5362118
  • Storage instructions

    Store at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overview

    Soluble in water
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1CC(N(C1)C(=O)C(CCCCN)NC(CCC2=CC=CC=C2)C(=O)O)C(=O)O.O.O
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:

  • Andújar-Sánchez M  et al. Thermodynamic determination of the binding constants of angiotensin-converting enzyme inhibitors by a displacement method. FEBS Lett 581:3449-54 (2007). Read more (PubMed: 17618628) »
  • Ozdemir HS  et al. Long-term lisinopril dihydrate application decreases plasma noradrenaline but not adrenaline levels in chickens. Physiol Res 49:183-8 (2000). Read more (PubMed: 10805421) »
  • Piepho RW Overview of the angiotensin-converting-enzyme inhibitors. Am J Health Syst Pharm 57 Suppl 1:S3-7 (2000). Read more (PubMed: 11030016) »
  • Cushman DW  et al. Comparisons in vitro, ex vivo, and in vivo of the actions of seven structurally diverse inhibitors of angiotensin converting enzyme (ACE). Br J Clin Pharmacol 28 Suppl 2:115S-130S; discussion 130S-131S (1989). Read more (PubMed: 2557876) »

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