Overview

  • Product name

  • Description

    Rabbit polyclonal to LITAF
  • Host species

    Rabbit
  • Tested applications

    Suitable for: WB, IHC-Pmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Recombinant full length protein corresponding to Human Tbx1 aa 1-161.
    Database link: Q99732

  • Positive control

    • K562, HeLa, HepG2 and BT474 cell line extracts.
  • General notes

     This product was previously labelled as LITAF

     

Properties

Applications

Our Abpromise guarantee covers the use of ab187533 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/2000. Predicted molecular weight: 17 kDa.
IHC-P 1/50 - 1/200.

ab171870 - Rabbit polyclonal IgG, is suitable for use as an isotype control with this antibody.

Target

  • Function

    Probable role in regulating transcription of specific genes. May regulate through NFKB1 the expression of the CCL2/MCP-1 chemokine. May play a role in tumor necrosis factor alpha (TNF-alpha) gene expression.
  • Tissue specificity

    Ubiquitously and abundantly expressed. Expressed predominantly in the placenta, peripheral blood leukocytes, lymph nodes and spleen.
  • Involvement in disease

    Defects in LITAF are the cause of Charcot-Marie-Tooth disease type 1C (CMT1C) [MIM:601098]. CMT1C is a form of Charcot-Marie-Tooth disease, the most common inherited disorder of the peripheral nervous system. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathy or CMT1, and primary peripheral axonal neuropathy or CMT2. Neuropathies of the CMT1 group are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet.
    Note=Defects in LITAF may be involved in extramammary Paget disease (EMPD) carcinogenesis. EMPD is a cancerous disease representing about 8% of all malignant skin cancers; it usually appears in the anogenital area and can be fatal by metastasizing to internal organs when left untreated for a long time. The clinical features are usually those of eczematous eruptions with weeping and crust formation.
  • Domain

    The WW-binding motif mediates interaction with WWOX and, probably NEDD4.
  • Cellular localization

    Lysosome membrane. Associated with membranes of lysosomes.
  • Information by UniProt
  • Database links

  • Alternative names

    • Lipopolysaccharide induced TNF alpha factor antibody
    • CMT1C antibody
    • FLJ38636 antibody
    • Lipopolysaccharide induced TNF alpha factor antibody
    • Lipopolysaccharide induced TNF factor antibody
    • Lipopolysaccharide induced tumor necrosis factor alpha factor antibody
    • Lipopolysaccharide-induced tumor necrosis factor-alpha factor antibody
    • LITAF antibody
    • LITAF_HUMAN antibody
    • LPS induced TNF alpha factor antibody
    • LPS-induced TNF-alpha factor antibody
    • MGC116698 antibody
    • MGC116700 antibody
    • MGC116701 antibody
    • MGC125274 antibody
    • MGC125275 antibody
    • MGC125276 antibody
    • p53 induced gene 7 protein antibody
    • p53-induced gene 7 protein antibody
    • PIG 7 antibody
    • PIG7 antibody
    • SIMPLE antibody
    • Small integral membrane protein of lysosome/late endosome antibody
    • TP53I7 antibody
    • Tumor protein p53 inducible protein 7 antibody
    see all

Images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of mouse lung tissue labelling Tbx1 with ab187533 at 1/200. Magnification: 400x.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human thyroid cancer tissue labelling Tbx1 with ab187533 at 1/200. Magnification: 400x.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human endometrial cancer tissue labelling Tbx1 with ab187533 at 1/200. Magnification: 400x.

  • All lanes : Anti-LITAF antibody (ab187533) at 1/500 dilution

    Lane 1 : K562 cell line extract
    Lane 2 : HeLa cell line extract
    Lane 3 : HepG2 cell line extract
    Lane 4 : BT474 cell line extract

    Predicted band size: 17 kDa

References

This product has been referenced in:

  • Li R  et al. A potential regulatory network among WDR86-AS1, miR-10b-3p, and LITAF is possibly involved in preeclampsia pathogenesis. Cell Signal 55:40-52 (2018). Read more (PubMed: 30552989) »
See 1 Publication for this product

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab187533.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES"
For licensing inquiries, please contact partnerships@abcam.com

Sign up