Key features and details
- Endogenous MDM2 and MDM4 selective inhibitor. Detergent.
- CAS Number: 434-13-9
- Purity: > 97%
- Soluble in ethanol and in DMSO
- Form / State: Solid
- Source: Synthetic
Product nameLithocholic acid, endogenous MDM2 and MDM4 selective inhibitor
DescriptionEndogenous MDM2 and MDM4 selective inhibitor. Detergent.
Biological descriptionEndogenous MDM2 and MDM4 selective inhibitor. Detergent. Solubilizes dietary fats for absorption. Increases p53 and cyclin D1 promoter activity and endogenous p53 and cyclin D1 expression and apoptosis. Shows cancer cell selective antiproliferative effects. Shows cholagogue and choleretic effects in vivo.
Chemical name(4R)-4-[(3R,5R,8R,9S,10S,13R,14S,17R)-3-Hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in ethanol and in DMSO
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.
- Signal Transduction
- Signaling Pathway
- Nuclear Signaling
- Nuclear Hormone Receptors
- Vitamin D Receptor
- Epigenetics and Nuclear Signaling
- Nuclear Signaling Pathways
- Nuclear Receptors
- Orphan Nuclear Receptors
- Pathways and Processes
- Metabolic signaling pathways
- Energy transfer pathways
- Energy Metabolism
To our knowledge, customised protocols are not required for this product. Please try the standard protocols listed below and let us know how you get on.
ab145598 has not yet been referenced specifically in any publications.