Recombinant
Recombinant Anti-Liver Arginase antibody [EPR6671(B)] (ab124917)
- Datasheet
- References (10)
- Protocols
Overview
-
Product name
Anti-Liver Arginase antibody [EPR6671(B)]
See all Liver Arginase primary antibodies -
Description
Rabbit monoclonal [EPR6671(B)] to Liver Arginase -
Host species
Rabbit -
Tested applications
Suitable for: WB, IPmore details
Unsuitable for: ICC/IF -
Species reactivity
Reacts with: Mouse, Rat, Human -
Immunogen
Synthetic peptide within Human Liver Arginase aa 1-100. The exact sequence is proprietary.
-
Positive control
- Fetal liver and mouse liver lysates.
-
General notes
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents.
This product is a recombinant rabbit monoclonal antibody.
Properties
-
Form
Liquid -
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
Storage buffer
pH: 7.20
Preservative: 0.05% Sodium azide
Constituents: 40% Glycerol, 9.85% Tris glycine, 50% Tissue culture supernatant -
Purity
Tissue culture supernatant -
Clonality
Monoclonal -
Clone number
EPR6671(B) -
Isotype
IgG -
Research areas
Associated products
-
Alternative Versions
-
Assay kits
-
Compatible Secondaries
-
Isotype control
-
Positive Controls
-
Recombinant Protein
Applications
Our Abpromise guarantee covers the use of ab124917 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | 1/1000 - 1/10000. Predicted molecular weight: 35 kDa. | |
| IP | 1/10 - 1/100. |
Application notes
Is unsuitable for ICC/IF.
Target
-
Pathway
Nitrogen metabolism; urea cycle; L-ornithine and urea from L-arginine: step 1/1. -
Involvement in disease
Defects in ARG1 are the cause of argininemia (ARGIN) [MIM:207800]; also known as hyperargininemia. Argininemia is a rare autosomal recessive disorder of the urea cycle. Arginine is elevated in the blood and cerebrospinal fluid, and periodic hyperammonemia occurs. Clinical manifestations include developmental delay, seizures, mental retardation, hypotonia, ataxia, progressive spastic quadriplegia. -
Sequence similarities
Belongs to the arginase family. -
Cellular localization
Cytoplasm. - Information by UniProt
-
Database links
- Entrez Gene: 383 Human
- Entrez Gene: 11846 Mouse
- Entrez Gene: 29221 Rat
- Omim: 608313 Human
- SwissProt: P05089 Human
- SwissProt: Q61176 Mouse
- SwissProt: P07824 Rat
- Unigene: 440934 Human
see all -
Alternative names
- A I antibody
- Al antibody
- ARG 1 antibody
see all
Images
-
![Western blot - Anti-Liver Arginase antibody [EPR6671(B)] (ab124917)](https://www.abcam.com/ps/products/124/ab124917/Images/ab124917-138917-anti-liver-arginase-antibody-epr6671b-western-blot.jpg)
Western blot - Anti-Liver Arginase antibody [EPR6671(B)] (ab124917)All lanes : Anti-Liver Arginase antibody [EPR6671(B)] (ab124917) at 1/1000 dilution
Lane 1 : Human fetal liver lysate
Lane 2 : Mouse liver lysate
Lysates/proteins at 10 µg per lane.
Secondary
All lanes : HRP labelled goat anti-rabbit at 1/2000 dilution
Predicted band size: 35 kDa
Datasheets and documents
References
This product has been referenced in:
- Yuan C et al. OAB-14, a bexarotene derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing ß-amyloid clearance in APP/PS1 mice. Biochim Biophys Acta Mol Basis Dis 1865:161-180 (2019). Read more (PubMed: 30389579) »
- Miller CN et al. Guggulsterone Activates Adipocyte Beiging through Direct Effects on 3T3-L1 Adipocytes and Indirect Effects Mediated through RAW264.7 Macrophages. Medicines (Basel) 6:N/A (2019). Read more (PubMed: 30709026) »
