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Anti-Liver Carboxylesterase 1/CES1 antibody - C-terminal (ab180705)

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Western blot - Anti-Liver Carboxylesterase 1/CES1 antibody - C-terminal (ab180705)

    Key features and details

    • Rabbit polyclonal to Liver Carboxylesterase 1/CES1 - C-terminal
    • Suitable for: WB
    • Reacts with: Mouse, Human
    • Isotype: IgG

    You may also be interested in

    Protein
    Recombinant Human Liver Carboxylesterase 1/CES1 protein (ab151864)
    Secondary
    Product image
    Goat Anti-Rabbit IgG H&L (HRP) (ab205718)

    View more associated products

    Overview

    • Product name

      Anti-Liver Carboxylesterase 1/CES1 antibody - C-terminal
      See all Liver Carboxylesterase 1/CES1 primary antibodies
    • Description

      Rabbit polyclonal to Liver Carboxylesterase 1/CES1 - C-terminal
    • Host species

      Rabbit
    • Tested Applications & Species

      Application Species
      WB
      Mouse
      See all applications and species data
    • Immunogen

      Recombinant fragment within Human Liver Carboxylesterase 1/CES1 aa 287-567 (C terminal). The exact sequence is proprietary.
      Sequence:

      RQKT EEELLETTLK MKFLSLDLQG DPRESQPLLG TVIDGMLLLK TPEELQAERN FHTVPYMVGI NKQEFGWLIP MQLMSYPLSE GQLDQKTAMS LLWKSYPLVC IAKELIPEAT EKYLGGTDDT VKKKDLFLDL IADVMFGVPS VIVARNHRDA GAPTYMYEFQ YRPSFSSDMK PKTVIGDHGD ELFSVFGAPF LKEGASEEEI RLSKMVMKFW ANFARNGNPN GEGLPHWPEY NQKEGYLQIG ANTQAAQKLK DKEVAFWTNL FAKKAVEKPP QTEHIEL


      Database link: P23141
      Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI
    • General notes

       This product was previously labelled as Liver Carboxylesterase 1

       

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing the problem with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation.

      One factor contributing to the crisis is the use of antibodies that are not suitable. This can lead to misleading results and the use of incorrect data informing project assumptions and direction. To help address this challenge, we have introduced an application and species grid on our primary antibody datasheets to make it easy to simplify identification of the right antibody for your needs.

      Learn more here.

    Properties

    • Form

      Liquid
    • Storage instructions

      Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
    • Storage buffer

      pH: 7.30
      Preservative: 0.02% Sodium azide
      Constituents: 49% PBS, 50% Glycerol
    • Concentration information loading...
    • Purity

      Immunogen affinity purified
    • Clonality

      Polyclonal
    • Isotype

      IgG
    • Research areas

      • Cardiovascular
      • Lipids / Lipoproteins
      • Lipid Metabolism
      • Cholesterol Metabolism
      • Cardiovascular
      • Lipids / Lipoproteins
      • Lipid Metabolism
      • Hydrolysis
      • Signal Transduction
      • Metabolism
      • Lipid metabolism
      • Signal Transduction
      • Metabolism
      • Drug metabolism
      • Metabolism
      • Pathways and Processes
      • Metabolic signaling pathways
      • Lipid and lipoprotein metabolism
      • Cholesterol Metabolism
      • Metabolism
      • Pathways and Processes
      • Metabolic signaling pathways
      • Lipid and lipoprotein metabolism
      • Hydrolysis
      • Metabolism
      • Pathways and Processes
      • Metabolic signaling pathways
      • Drug metabolism

    Associated products

    • Compatible Secondaries

      • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
      • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
    • Isotype control

      • Rabbit IgG, polyclonal - Isotype Control (ChIP Grade) (ab171870)
    • Positive Controls

      • Mouse liver tissue lysate - total protein (ab29301)
      • A549 whole cell lysate (ab7910)
    • Recombinant Protein

      • Recombinant Human Liver Carboxylesterase 1/CES1 protein (ab151864)

    Applications

    The Abpromise guarantee

    Our Abpromise guarantee covers the use of ab180705 in the following tested applications.

    The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

    Guaranteed

    Tested applications are guaranteed to work and covered by our Abpromise guarantee.

    Predicted

    Predicted to work for this combination of applications and species but not guaranteed.

    Incompatible

    Does not work for this combination of applications and species.

    Application Species
    WB
    Mouse
    All applications
    Rat
    Application Abreviews Notes
    WB
    1/500 - 1/2000. Predicted molecular weight: 62 kDa.
    Notes
    WB
    1/500 - 1/2000. Predicted molecular weight: 62 kDa.

    Target

    • Function

      Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Hydrolyzes aromatic and aliphatic esters, but has no catalytic activity toward amides or a fatty acyl-CoA ester. Hydrolyzes the methyl ester group of cocaine to form benzoylecgonine. Catalyzes the transesterification of cocaine to form cocaethylene. Displays fatty acid ethyl ester synthase activity, catalyzing the ethyl esterification of oleic acid to ethyloleate.
    • Tissue specificity

      Expressed predominantly in liver with lower levels in heart and lung.
    • Sequence similarities

      Belongs to the type-B carboxylesterase/lipase family.
    • Post-translational
      modifications

      Contains sialic acid.
      Cleavage of the signal sequence can occur at 2 positions, either between Trp-17 and Gly-18 or between Gly-18 and His-19.
    • Cellular localization

      Endoplasmic reticulum lumen.
    • Target information above from: UniProt accession P23141 The UniProt Consortium
      The Universal Protein Resource (UniProt) in 2010
      Nucleic Acids Res. 38:D142-D148 (2010) .

      Information by UniProt
    • Database links

      • Entrez Gene: 1066 Human
      • Entrez Gene: 12623 Mouse
      • Entrez Gene: 24346 Rat
      • Entrez Gene: 29225 Rat
      • Omim: 114835 Human
      • SwissProt: P23141 Human
      • SwissProt: Q8VCC2 Mouse
      • SwissProt: P10959 Rat
      • SwissProt: Q63108 Rat
      • Unigene: 558865 Human
      • Unigene: 22720 Mouse
      • Unigene: 2549 Rat
      see all
    • Alternative names

      • ACAT antibody
      • Acyl coenzyme A cholesterol acyltransferase antibody
      • Acyl-coenzyme A:cholesterol acyltransferase antibody
      • Brain carboxylesterase hBr1 antibody
      • Carboxyesterase ES-3 antibody
      • Carboxylesterase antibody
      • Carboxylesterase 1 (monocyte/macrophage serine esterase 1) antibody
      • Carboxylesterase 1 antibody
      • Carboxylesterase 1 deficiency, included antibody
      • Carboxylesterase 2, formerly antibody
      • CE 1 antibody
      • CEH antibody
      • Ces-1 antibody
      • CES1 antibody
      • CES2 antibody
      • CESDD1 antibody
      • Cholesterol ester hydrolase, neutral, macrophage-derived antibody
      • Cholesteryl ester hydrolase antibody
      • Cocaine carboxylesterase antibody
      • EC 3.1.1.1 antibody
      • Egasyn antibody
      • ES-HTEL antibody
      • ES-x antibody
      • Es22 antibody
      • EST1_HUMAN antibody
      • Esterase 22 antibody
      • Esterase antibody
      • hCE 1 antibody
      • HMSE antibody
      • HMSE1 antibody
      • Liver carboxylesterase 1 antibody
      • Liver carboxylesterase 3 antibody
      • Methylumbelliferyl acetate deacetylase 1 antibody
      • MGC117365 antibody
      • MGC156521 antibody
      • Monocyte carboxylesterase deficiency, included antibody
      • Monocyte esterase deficiency, included antibody
      • Monocyte/macrophage serine esterase antibody
      • PCE-1 antibody
      • pI 5.5 esterase antibody
      • Proline-beta-naphthylamidase antibody
      • REH antibody
      • Retinyl ester hydrolase antibody
      • Serine esterase 1 antibody
      • Ses-1 antibody
      • SES1 antibody
      • TGH antibody
      • Triacylglycerol hydrolase antibody
      see all

    Images

    • Western blot - Anti-Liver Carboxylesterase 1/CES1 antibody - C-terminal (ab180705)
      Western blot - Anti-Liver Carboxylesterase 1/CES1 antibody - C-terminal (ab180705)
      All lanes : Anti-Liver Carboxylesterase 1/CES1 antibody - C-terminal (ab180705) at 1/500 dilution

      Lane 1 : Mouse liver cell extract
      Lane 2 : A549 cell extract
      Lane 3 : U937 cell extract

      Predicted band size: 62 kDa

    Protocols

    • Western blot protocols

    Click here to view the general protocols

    Datasheets and documents

    • SDS download

    • Datasheet download

      Download

    References (0)

    Publishing research using ab180705? Please let us know so that we can cite the reference in this datasheet.

    ab180705 has not yet been referenced specifically in any publications.

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