• Product name

    Anti-Livin antibody [88C570]
    See all Livin primary antibodies
  • Description

    Mouse monoclonal [88C570] to Livin
  • Host species

  • Tested applications

    Suitable for: Flow Cyt, WBmore details
  • Species reactivity

    Reacts with: Human
  • Immunogen

    Recombinant fusion protein (Human Livin).

  • Positive control

    • Cell extracts transfected with human Livin cDNA.



Our Abpromise guarantee covers the use of ab11983 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Flow Cyt Use 1µg for 106 cells.

ab170190 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.


WB Use a concentration of 1 - 2 µg/ml. Detects a band of approximately 31 kDa.


  • Function

    Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits caspase-3 and proteolytic activation of pro-caspase-9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis.
  • Tissue specificity

    Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal muscle and peripheral blood leukocytes.
  • Sequence similarities

    Belongs to the IAP family.
    Contains 1 BIR repeat.
    Contains 1 RING-type zinc finger.
  • Cellular localization

    Nucleus. Cytoplasm. Nuclear, and in a filamentous pattern throughout the cytoplasm.
  • Information by UniProt
  • Database links

  • Alternative names

    • Baculoviral IAP repeat containing 7 antibody
    • Baculoviral IAP repeat containing protein 7 antibody
    • Baculoviral IAP repeat-containing protein 7 antibody
    • BIRC 7 antibody
    • birc7 antibody
    • BIRC7_HUMAN antibody
    • KIAP antibody
    • Kidney inhibitor of apoptosis protein antibody
    • Livin antibody
    • Livin inhibitor of apotosis antibody
    • Melanoma inhibitor of apoptosis protein antibody
    • ML IAP antibody
    • ML-IAP antibody
    • MLIAP antibody
    • RING finger protein 50 antibody
    • RNF 50 antibody
    • RNF50 antibody
    see all


  • Livin detection by Western blot. The detection of Livin in cell extract transfected with human Livin cDNA. A protein of 31 kDa was detected by using anti-Livin at a 2 µg/ml dilution. Livin detection by Western blot. The detection of Livin in cell extract transfected with human Livin cDNA. A protein of 31 kDa was detected by using anti-Livin at a 2 µg/ml dilution.
  • Overlay histogram showing HeLa cells stained with ab11983 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab11983, 1µg/1x106 cells) for 30 min at 22ºC. The secondary antibody used was DyLight® 488 goat anti-mouse IgG (H+L) (ab96879) at 1/500 dilution for 30 min at 22ºC. Isotype control antibody (black line) was mouse IgG1 [ICIGG1] (ab91353, 2µg/1x106 cells) used under the same conditions. Acquisition of >5,000 events was performed.


ab11983 has not yet been referenced specifically in any publications.

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