Overview

  • Product name

  • Description

    Rabbit polyclonal to LLGL1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: IHC-Pmore details
  • Species reactivity

    Reacts with: Rat
    Predicted to work with: Mouse, Human
  • Immunogen

    Synthetic peptide within Human LLGL1 aa 820-870 conjugated to keyhole limpet haemocyanin. The exact sequence is proprietary.
    Database link: Q15334

  • Positive control

    • Rat brain tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab203581 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500.

(or 1/50 - 1/200 using a fluorescent secondary antibody).

Target

  • Function

    Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells.
  • Tissue specificity

    Expressed in brain, kidney, and muscle but is barely seen in heart and placenta. Down-regulated or lost in all cell lines and in most of the tumor samples analyzed. Loss was associated with advanced stage of the disease.
  • Sequence similarities

    Belongs to the WD repeat L(2)GL family.
    Contains 14 WD repeats.
  • Post-translational
    modifications

    Phosphorylated upon DNA damage, probably by ATM or ATR (By similarity). Phosphorylated at least at Ser-663 by PRKCI.
  • Cellular localization

    Cytoplasm > cytoskeleton. Localized to the lateral membrane during the polarization and formation cell-cell contacts.
  • Information by UniProt
  • Database links

  • Alternative names

    • DLG4 antibody
    • DLG4, formerly antibody
    • Hugl 1 antibody
    • HUGL antibody
    • Hugl-1 antibody
    • HUGL1 antibody
    • Human homolog to the D-lgl gene protein antibody
    • L2GL1_HUMAN antibody
    • Lethal giant larvae homolog 1 (Drosophila) antibody
    • Lethal giant larvae homolog 1 antibody
    • Lethal(2) giant larvae protein homolog 1 antibody
    • LLGL antibody
    • Llgl1 antibody
    • Ly 49G2 antibody
    • Ly49G2 antibody
    • Mgl1 antibody
    • Mlgl antibody
    see all

Images

  • Immunohistochemical analysis of formalin-fixed, paraffin-embedded rat brain tissue labeling Lgl1 with ab203581 at 1/200 dilution, followed by secondary antibody and DAB staining.

References

ab203581 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab203581.
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