Overview

  • Product name

    LM11A-31, nonpeptide p75NTR ligand
  • Description

    Selective nonpeptide p75NTR ligand
  • Biological description

    Selective nonpeptide p75NTR ligand. Blocks p75-mediated cell death. Promotes neurogenesis and neurite survival. Does not affect NGF binding to TrkA. Shows neuroprotective and neuroregenerative effects in vivo. Orally active. Blood-brain barrier permeable.
  • CAS Number

    1243259-19-9
  • Chemical structure

    Chemical Structure

Properties

References

This product has been referenced in:

  • Grabenstatter HL  et al. Acute administration of the small-molecule p75(NTR) ligand does not prevent hippocampal neuron loss or development of spontaneous seizures after pilocarpine-induced status epilepticus. J Neurosci Res 92:1307-18 (2014). Read more (PubMed: 24801281) »
  • Nguyen TV  et al. Small molecule p75NTR ligands reduce pathological phosphorylation and misfolding of tau, inflammatory changes, cholinergic degeneration, and cognitive deficits in AßPP(L/S) transgenic mice. J Alzheimers Dis 42:459-83 (2014). Read more (PubMed: 24898660) »
  • Simmons DA  et al. A small molecule p75NTR ligand, LM11A-31, reverses cholinergic neurite dystrophy in Alzheimer's disease mouse models with mid- to late-stage disease progression. PLoS One 9:e102136 (2014). Read more (PubMed: 25153701) »

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