LM22A-4, neurotrophic BDNF mimetic (ab222020)

Overview

  • Product name

    LM22A-4, neurotrophic BDNF mimetic
  • Description

    Neurotrophic BDNF mimetic; Partial TrkB agonist.
  • Biological description

    Small molecule BDNF mimetic displaying neurotrophic activity. Partial agonist at TrkB, activating TrkB signaling. Displaces BDNF (IC50 = 47 nM) in binding assays. Prevents neuronal degeneration with equal efficacy to that of BDNF in in vitro models of neurodegenerative disease. Causes hippocampal and striatal TrkB activation in mice and improved motor learning after traumatic brain injury in rats, after in vivo administraton. Improves respiratory function in a mouse model of Rett syndrome.

  • Purity

    > 98%
  • CAS Number

    37988-18-4
  • Chemical structure

    Chemical Structure

Properties

  • Chemical name

    N,N',N''-Tris(2-hydroxyethyl)-1,3,5-benzenetricarboxamide
  • Molecular weight

    339.35
  • Molecular formula

    C15H21N3O6
  • PubChem identifier

    2054170
  • Storage instructions

    Shipped at room temperature. Store at -20°C.
  • Solubility overview

    Soluble in water to 100 mM and in DMSO to 100 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES

    C1=C(C=C(C=C1C(=O)NCCO)C(=O)NCCO)C(=O)NCCO
  • Source

    Synthetic

References

This product has been referenced in:

  • Kajiya M  et al. BDNF mimetic compound LM22A-4 regulates cementoblast differentiation via the TrkB-ERK/Akt signaling cascade. Int Immunopharmacol 19:245-52 (2014). Read more (PubMed: 24530412) »
  • Schmid DA  et al. A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome. J Neurosci 32:1803-10 (2012). Read more (PubMed: 22302819) »
  • Massa SM  et al. Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. J Clin Invest 120:1774-85 (2010). Read more (PubMed: 20407211) »

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Please note: All products are "FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC PROCEDURES, NOT FOR USE IN HUMANS"
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