Overview

  • Product name

  • Description

    Rabbit polyclonal to LMAN1
  • Host species

    Rabbit
  • Tested applications

    Suitable for: ICC/IF, WBmore details
  • Species reactivity

    Reacts with: Mouse, Rat, Human
  • Immunogen

    Synthetic peptide:

    FDSFDNDGKKNNPAI

    , corresponding to amino acids 159-173 of Rat LMAN1

  • Positive control

    • Rat brain lysate.

Properties

Applications

Our Abpromise guarantee covers the use of ab32583 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF Use at an assay dependent concentration.
WB 1/1000. Detects a band of approximately 57.5 kDa.

Target

  • Function

    Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.
  • Tissue specificity

    Ubiquitous.
  • Involvement in disease

    Defects in LMAN1 are THE cause of factor V and factor VIII combined deficiency type 1 (F5F8D1) [MIM:227300]; also known as multiple coagulation factor deficiency I (MCFD1). F5F8D1 is an autosomal recessive blood coagulation disorder characterized by bleeding symptoms similar to those in hemophilia or parahemophilia, that are caused by single deficiency of FV or FVIII, respectively. The most common symptoms are epistaxis, menorrhagia, and excessive bleeding during or after trauma. Plasma levels of coagulation factors V and VIII are in the range of 5 to 30% of normal.
  • Sequence similarities

    Contains 1 L-type lectin-like domain.
  • Post-translational
    modifications

    The N-terminal may be partly blocked.
  • Cellular localization

    Endoplasmic reticulum-Golgi intermediate compartment membrane. Golgi apparatus membrane. Endoplasmic reticulum membrane.
  • Information by UniProt
  • Database links

  • Alternative names

    • Endoplasmic reticulum golgi intermediate compartment protein 53 antibody
    • ER-Golgi intermediate compartment 53 kDa protein antibody
    • ERGIC-53 antibody
    • ERGIC53 antibody
    • ERGIC53 like protein antibody
    • F5F8D antibody
    • FMFD1 antibody
    • Gp58 antibody
    • Intracellular mannose specific lectin antibody
    • Intracellular mannose-specific lectin MR60 antibody
    • Lectin mannose binding 1 antibody
    • Lectin mannose-binding 1 antibody
    • Lman1 antibody
    • LMAN1 like protein antibody
    • LMAN1_HUMAN antibody
    • MCFD1 antibody
    • MR60 antibody
    • Protein ERGIC-53 antibody
    see all

Images

  • ab32583 labelling LMAN1 in p19 cells by Immunocytochemistry/Immunofluorescence.

  • ab32583 labelling LMAN1 in HMVEC cells by Immunocytochemistry/Immunofluorescence.

  • ab32583 labelling LMAN1 in A549 cells by Immunocytochemistry/Immunofluorescence.

  • All lanes : Anti-LMAN1 antibody (ab32583) at 1/1000 dilution

    Lane 1 : Rat brain lysate
    Lane 2 : Rat brain lysate with Immunising peptide

    Observed band size: 57.5 kDa
    why is the actual band size different from the predicted?

References

ab32583 has not yet been referenced specifically in any publications.

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