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Rabbit monoclonal [EPR6980] to LMAN1
ICC/IF more details Unsuitable for:
Flow Cyt or IP
Mouse, Rat, Human
A synthetic peptide corresponding to residues in Human LMAN1 (P49257).
HeLa cell lysates
NCI-H460 cell lysates
JAR cell lysates
Papillary adenocarcinoma tissue
® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab ® patents
This product is a recombinant rabbit monoclonal antibody.
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Dissociation constant (K
Preservative: 0.01% Sodium azide Constituents: 9% PBS, 40% Glycerol, 0.05% BSA, 50% Tissue culture supernatant
Tissue culture supernatant
Abpromise guarantee covers the use of
in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1/1000 - 1/10000. Predicted molecular weight: 58 kDa.
1/50 - 1/100. Antigen retrieval is recommended.
1/100 - 1/250.
Is unsuitable for Flow Cyt or IP.
Mannose-specific lectin. May recognize sugar residues of glycoproteins, glycolipids, or glycosylphosphatidyl inositol anchors and may be involved in the sorting or recycling of proteins, lipids, or both. The LMAN1-MCFD2 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.
Involvement in disease
Defects in LMAN1 are THE cause of factor V and factor VIII combined deficiency type 1 (F5F8D1) [MIM:227300]; also known as multiple coagulation factor deficiency I (MCFD1). F5F8D1 is an autosomal recessive blood coagulation disorder characterized by bleeding symptoms similar to those in hemophilia or parahemophilia, that are caused by single deficiency of FV or FVIII, respectively. The most common symptoms are epistaxis, menorrhagia, and excessive bleeding during or after trauma. Plasma levels of coagulation factors V and VIII are in the range of 5 to 30% of normal.
Contains 1 L-type lectin-like domain.
The N-terminal may be partly blocked.
Endoplasmic reticulum-Golgi intermediate compartment membrane. Golgi apparatus membrane. Endoplasmic reticulum membrane.
Information by UniProt
Endoplasmic reticulum golgi intermediate compartment protein 53 antibody
ER-Golgi intermediate compartment 53 kDa protein antibody
Western blot - Anti-LMAN1 antibody [EPR6980] (ab126720)
All lanes : Anti-LMAN1 antibody [EPR6980] (ab126720) at 1/1000 dilution Lane 1 : HeLa cell lysates Lane 2 : NCI-H460 cell lysates Lane 3 : JAR cell lysates Predicted band size: 58 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LMAN1 antibody [EPR6980] (ab126720)
ab126720, at 1/50 dilution, stains LMAN1 in paraffin-embedded papillary adenocarcinoma tissue by immunohistochemistry.
Other - Anti-LMAN1 antibody [EPR6980] (ab126720)
has not yet been referenced specifically in any publications.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"